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Is Akurit 4 Safe For Liver?
Question: Hello Dr,
I have been diagonised with TB PCR during a laproscopy surgery for ovarian drilling. I hv been put on akurit 4 since may 21st'14. I read many posts here that it causes liver problems and Iam now worried. Does it really harm liver ? How often should I get LFTs done to keep a check on it ?
I have been diagonised with TB PCR during a laproscopy surgery for ovarian drilling. I hv been put on akurit 4 since may 21st'14. I read many posts here that it causes liver problems and Iam now worried. Does it really harm liver ? How often should I get LFTs done to keep a check on it ?
Brief Answer:
Yes,it causes liver damage.
Detailed Answer:
Hello XXXX
Thanks for writing to HCM
Akurit 4 contains four antitubercular medicines and it contains Isoniazid ,Rifampicin,Pyrazinamide and Ethambutol.
Before starting Akurit 4,patient should have baseline serum uric acid and liver function test like SGPT and SGOT(SGPT is most important).
Liver damage is due to Isoniazid,Rifampicin and Pyrazinamide.Monthly assessment of SGPT should be done throughout the treatment.
In patients with liver dysfunction,monitoring of SGOT and SGPT should be done every 2 weeks throughout the treatment.
Get well soon.
Hope I have answered your question.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Yes,it causes liver damage.
Detailed Answer:
Hello XXXX
Thanks for writing to HCM
Akurit 4 contains four antitubercular medicines and it contains Isoniazid ,Rifampicin,Pyrazinamide and Ethambutol.
Before starting Akurit 4,patient should have baseline serum uric acid and liver function test like SGPT and SGOT(SGPT is most important).
Liver damage is due to Isoniazid,Rifampicin and Pyrazinamide.Monthly assessment of SGPT should be done throughout the treatment.
In patients with liver dysfunction,monitoring of SGOT and SGPT should be done every 2 weeks throughout the treatment.
Get well soon.
Hope I have answered your question.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Then what is the alternate medicine to akurit 4, which does not cause liver damage and also should be equally effective in curing TB PCR as akurit4. ?
In case I need to continue akurit4 what are the precautions to be taken in form of diet and additional medicines to safe gaurd liver
In case I need to continue akurit4 what are the precautions to be taken in form of diet and additional medicines to safe gaurd liver
Brief Answer:
Please find detail answer below.
Detailed Answer:
Hello XXXX
Thanks for writing back
Drugs contained in Akurit 4 are the first line drugs for Tuberculosis.
Other medicines are advised in resistant T.B.
You shouldn't be so worried.These are highly efficacious drugs and it should be tried first.First you need baseline SGPT and uric acid so that any adverse effects can be compared later on.In most of the cases of liver toxicity,only dose adjustment is required with continuation of same drugs.
You should high protein diet.
Get well soon.
Hope I have answered your question.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Please find detail answer below.
Detailed Answer:
Hello XXXX
Thanks for writing back
Drugs contained in Akurit 4 are the first line drugs for Tuberculosis.
Other medicines are advised in resistant T.B.
You shouldn't be so worried.These are highly efficacious drugs and it should be tried first.First you need baseline SGPT and uric acid so that any adverse effects can be compared later on.In most of the cases of liver toxicity,only dose adjustment is required with continuation of same drugs.
You should high protein diet.
Get well soon.
Hope I have answered your question.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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