
Is CMIA DUO Test Done Post 28 Days Of Exposure Conclusive?

Now I am feeling sore throat also I didn't sleep from past few weeks I sweat a alot in day and night and I am in depression and fear of HIV I read all day and night about HIV which make me more tired and weak I always feel back side knee pain I heard that duo test is good at 28th day a lot of negative thoughts are coming in my mind the girl send me some reports about HIV on my number but I didn't know her name how can I trust her but I am feeling heat and weak while walking also. Only negative thoughts comes in my mind why I had flu at this point of time why I had red rahes on my chest and one on arm on this point of time .is I am infected I feel nausea by this ,my leg and hand muscles vibrates some time I think I lost all my life in few time I cry and feel guilty my white blood cell show little above the boder line which also increase my anxiety and fear
You are free from HIV 1 infection beyond any doubt.
Detailed Answer:
Hi,
Welcome to HCM.
Thanks for posting your query.
All the symptoms described by you are vague and not specific to HIV. You had safe sex twice. Once you are doubtful about the safety.
Your CMIA DUO test from Lal Path lab. is quite reliable. A non-reactive test by 28 days after the exposure had ruled out the possibility of HIV 1 infection. This test comprises of two parts. P24 antigen part of the test is now reliable whereas the antibody part of the test will be reliable after the competition of the window period (6-8 weeks, up to 12 weeks). HIV 1 infection is the most commonest HIV infection up to the extent of 99 % or above.
HIV 2 infection prevalence is less than 0.5% throughout the world except in certain parts of XXXXXXX
So you need not worry. If you have any symptoms, they are not related to HIV infection and consult your physician and get well soon. Anxiety also can produce such symptoms.
Dr S Murugan


Sir should I have to do more test in future or any other std tests. I read online that 4th gen test is 95% conclusive on 28 day but the 5% and my symptoms I never had red blisters/spots befor add to my anxiety .my physician say that I may go in depression if I act like this when I ask him question on phone . but only patient like me can understand what we are going through . I swear I will not go to such places sir I am In biggest tramau I can't have proper sleep .I search a lot on net all organization/sites have different views over the tests and accuracy .
Your symptoms are due to anxiety.Your test is reliable up to 99.9 %
Detailed Answer:
Hi,
Welcome back.
There is nothing to worry so much.
I have more than 25 years of experience with HIV disease and patients.
No test is 100% fool proof. At the same time your 4th generation HIV test is almost 99.9% sensitive.
(http://www.aidsmap.com/Accuracy/page/0000/)
By ruling out HIV 1 infection, you are sure that you are free from HIV infection to the extent of 99.5%.
HIV 2 infection can be ruled by a ELISA or rapid test 12 weeks after the exposure. If you want to rule out earlier there is one Qualitative RNA PCR test for HIV 2 infection is available with very certain laboratories. You can have the test and rule out HIV 2 without waiting till 12 weeks.
All your symptoms are due to your anxiety. Follow the advice of your psychiatrist. If necessary you could meet him frequently to have frequent counselling.
Dr S.Murugan


Sir I ask the dr lal path but they don't have pcr RNA test for HIV 2 they have for HIV 1 only . do I have chance of HIV 2 . I heard that there are around 800 cases of HIV 2 reported in XXXXXXX do duo test at 18 day is inficient?
I know my symptoms are typical that's why I am worried.
The possibility of HIV 2 infection is unlikely
Detailed Answer:
Hi,
Welcome back.
Antigens can be detected as early as 7 days after the infection, but the test can be considered conclusive by 3-4 weeks after the exposure.
HIV 2 infection in XXXXXXX is a rare possibility.
As you had 2 protected exposures and the other doubtful or partially protected. So the possibility of HIV 2 infection is unlikely.
Dr S Murugan


Qualitative RNA PCR for HIV 2 infection is highly reliable.
Detailed Answer:
Hi,
Welcome back.
HIV 2 infection is rare. It is less than 0.5%. So the test is not necessary for you as you had protected intercourse. Only for your satisfaction, you can undertake the test for HIV 2. Qualitative RNA PCR for HIV 2 infection is a highly reliable test 3 weeks after the exposure. So you can go for the test if you want.
Dr S Murugan


2. Sir what is difference between 4th gen and 5th gen test ?
3. Is there any need of more duo test after the 28 days
Rule out HIV 2 infection after completion of window period.
Detailed Answer:
Hi,
Welcome back.
As far my knowledge goes, there is nothing like 5th generation test.
Nothing to worry. You wait till 12 weeks and have the HIV ELISA or Tridot test and rule out the possibility of HIV 2 infection also. There is no harm in waiting. It will also come non-reactive only.
Dr S Murugan


I have white tounge also
. Can sharing ciggeret with a HIV person can cause HIV ?? No blood contact
And licking you own hand which may have her varginal fluid?
Your acts carry a negligible risk for HIV.
Detailed Answer:
Hi,
Welcome back.
Sharing cigarette with a HIV positive individual is not a risky attitude for HIV. Putting the fingers contaminated with Vaginal fluid into the mouth carries a negligible risk for HIV infection. You can have the HIV 2 RNA PCR test 50 days after the incident. It is highly reliable.
Dr S Murugan


Do Dr lal path lab are no match of SLR as 4th gen test in Dr lal is of 450 only where in SLR they have it for 850
Also SLR have Rs.1200 for p24 test separate do there testing standard differ Dr lal uses cima method for 4th generation can I trust the dr lal path report for 4th generation has I tested thrice the index value always came 0.07 I know which is good but I just asking there is no doubt on Dr lal path lab testing methods?
Sir do DNA pcr which SLR lab offer tested for HIV 2 or not? I asked the lab person but he did not know much
Both labs are equally good
Detailed Answer:
Hi,
Welcome back.
SRL Lab and Lal path are equally good. Sometimes we doctors are not happy with SRL reports and sometimes this had happened with Lal path also. So with one or two incident we can not qualify them. Overall they are good and reliable laboratories. Moreover we can not quantify them with their cost for a particular test. We used come across such situation in any other items with the name of the popular companies.
Similarly if you get the same cut off value each time means that their standard is good only. I am not aware whether SRL has qualitative HIV 2 RNA PCR test or not.
Dr s XXXXXXX


I feel burning sensation in kness and groin and stomach
You are free from HIV 1 infection. Your symptoms are not related to HIV.
Detailed Answer:
Hi,
Welcome back.
Still your test showed a negative result only. The value of the test has nothing to do with the viral activity. It is just an expression.
HIV 2 infection would not be able to predict by the 4th generation DUO test before the window period is over.
Your symptoms are not related to HIV.
You need not go for HIV 2 RNA PCR. You can have the 4th generation DUO test 12 weeks after the last exposure and rule out the negligible possibility.
DR S.Murugan


Sir I read some where that antibody also formed within 6 weeks in most of the people?
HIV Antibodies can occur within 6-8 weeks in presence of an infection.
Detailed Answer:
Hi,
Welcome back.
Your symptoms are unlikely be due to HIV.
RNA PCR is reliable at any stage of HIV disease till his end. It will be highly reliable 46 days after the risky contact. Antibodies can appear well within 6-8 weeks in most of the individuals, in the presence of an infection, in some individuals it will be delayed up to 12 weeks rarely. So the test after 12 weeks can be considered more conclusive.
Dr S.Murugan


Free from HIV 1 and 2 infection. Your symptoms are not related to HIV.
Detailed Answer:
Hi,
Welcome back.
Congratulations. You are free from HIV 1 and 2 infection. Psychiatrist are not the authority as far as the HIV testing is concerned. Consult your physician and get cured from all your symptoms which are not at all due to HIV.
Dr S.Murugan


Sir I don't know why I got these symptoms at this point of time I have changed a lot of physician but found no cure to my situation the rahese didn't fade way I read online that some HIV patient have reddot in plam which increase my fear I undergo HIV 2 pcr test at 46th day and 4th gen test at 26th day as you said
Sir they are conclusive? I really not able to come out of this. Today I maturbate after a 40 days gape but still the cum was so light like water only . I fell something is different . I don't know what to do I didn't getting my normal life back I cry some time people use to say what happened to you you are getting weaker day by day . I took complete bed rest for 25-30 day but still didn't recovery and felling sick ,sunburn many times . I didn't went to any HIV specialist but I went to physciatrist , one say you are fine and give depression and anxiety pills and other say test at 3 month and 6 month but none physician antibiotics helped me to get well . sir are these test are reliable as done from Dr lal path lab I heard XXXXXXX labs are good now. I have spent lot of time and money but still didn't getting well and have fear
Your symptoms are not related to HIV.
Detailed Answer:
Hi,
Welcome back.
Your 4th generation test after 28 days and HIV 2 RNA PCR test are very much conclusive and Lal Path lab is reliable. Your symptoms are not related to HIV infection. Not to worry about HIV.
Dr S Murugan


Sir means I can forget this incident and not to tell the physicians about this as they may related it to this incident . should go as a normal patients now? Sir please help me to get out from this trauma I always think of negative thoughts I know I am more mentally ill as compared to physically but these physciatrist didn't helped me much neither the physicians . so should I forget this 2 incident the condom broke with unknow and cigreet sharing with HIV person.
Your symptoms are not related to HIV.
Detailed Answer:
Hi,
Welcome back.
Your negative 4th generation test by 28 days ruled out the possibility of HIV 1 infection.
Your undetectable HIV 2 RNA PCR on 46th day ruled out HIV 2 infection. So you can go to your physician and not necessary to disclose to him about these incident. You simply forget those incident. Summer heat or lack of water alone could not be blamed for your problem.
If you can, you can meet me in person at my clinic at XXXXXXX Tamilnadu.
Get well soon.
Dr S.Murugan


Sharing the cigarette has not much risk for HIV infection.
Detailed Answer:
Hi,
Welcome back.
26 and 28 days are not going to make much difference. Your report on 26th day also was conclusive as far as the P24 antigen test was concerned. The value has no importance. Only the negative result that has value. Sharing the cigarette has not much risk for HIV infection.
Dr S Murugan


2.Sir do you think any need of HIV test in future after my duo at 26 day and HIV 2 pcr RNA test at 46 ?
You really helped me with your words no doctor till now help me so much .
No further test for HIV is necessary for you.
Detailed Answer:
Hi,
Welcome back.
Clear fluid comes during sexual excitement is nothing but normal precum. Constipation and prolonged sexual abstinence leads to semen like flow during strain for stools is also common, not necessarily related to STD. Consult a STD physician for further help. You need no further test for HIV.
Dr S Murugan


Sir I am thinking for going STD panel test form Dr lal path lab.
Your symptoms are unlikely be due to HIV/STD
Detailed Answer:
Hi,
Welcome back.
Muscular twitching can occur due to calcium deficiency or due to fatigue.
Regarding your skin rash and itching of penis, consult a Dermatologist and get well soon. Itching of penis could be due to some fungal infection (yeast), or due to some irritation.
Your STD panel test will be likely to come as negative.
Dr S.Murugan


HSV is not a life threatening disease
Detailed Answer:
Hi,
Welcome back.
I am not able to see the reports sent by you in this website.
Herpes simplex infection over chest and face are unusual. Scattered lesions over the body also is uncommon.
People living with HSV are living happily for years together. It is not a life threatening disease. Transmission to baby from mother is uncommon in our country.
Dr S Murugan


Indicates older infection, possibly HSV 2 infection
Detailed Answer:
Hi,
Welcome back.
Nothing much to worry.
HSV 1 infection is not a STD whereas HSV 2 infection is a sexually transmitted disease. HSV 1 infection is so common even from childhood onwards. Nearly 40-50% of any population are having antibodies against HSV 1. It is a very minor disease and remain symptomless with many. Your test for HSV not specific for HSV 1 or 2 infection, but performed together. That too, IgG antibodies indicate a older infection (prior to 6 months), and not a recent infection. It is not necessarily HSV 2 infection, possibly HSV 1 infection, which is a harmless one. Not to worry.
Dr S Murugan


Symptoms are unlikely to be due to HSV
Detailed Answer:
Hi,
Welcome back.
HSV IgG antibodies positive clearly indicates that this report is not at all related to your activities during May. Your symptoms are unlikely due to HSV. It could possibly be Acne (chest, shoulder and face). Forget about those incidents. Ignore HSV antibodies.
Dr S Murugan


Everyday I woke up with fatigue, sore throat and pain in knees which was from many days but today I observe swollen armpit . sir I went to dermatologist he say the rashes are not by hsv and he gave some me some medicine . sir I am afraid I have feeling of sick and can even walk much , always feel low on energy . sir I kknow I am clear of HIV 1 because I have done 5-6 4th gen test but I have still fear of HIV 2 because I read on net HIV 2 show low replication and take time to show positive on antibody test my last antibody test was done after 52 day of high exposure and 40 day of my last sex activity after which within 6 days i get sick .
I read that HIV 2 pcr RNA may miss HIV 2 the as it may have low viral load and test can only detected 900ml/copies . my last 4th gen test was taken exactly after 1 month of my illness.
I run clacium and vitamins tests also but all comes all right but still I have weakness and muscle twitching. Sir I have lost 6 kg weight in 1 month . please help
Your symptoms are unlikely to be due to HIV
Detailed Answer:
Hi,
Welcome back.
The prevalence of HIV 2 infection is less than 0.5% throughout the world except in certain parts of XXXXXXX Missing of detection of HIV 2 infection through HIV 2 PCR test is unlikely. Extreme weakness as a symptom in early HIV 2 infection is unusual. Your symptoms are unlikely to be due to HIV. Antibody test prior to 8 weeks after the exposure (including 4th generation test) cannot be very much reliable. A good physician can treat your symptoms successfully.
Dr S Murugan


You need no further test for HIV.
Detailed Answer:
Hi,
Welcome back.
All people can not be expert in all specialties including your psychiatrist and your sexologist and myself. Each one has own their expertise in some field or other. Moreover alternate system has no adequate base in their system.
Regarding HIV, I think that I can extend some opinion better than them as I have engaged myself in the field of HIV medicine more than 27 years. I used to update my knowledge then and there by attending national level and international conferences as a delegate, chair person and faculty.
So you can rely my words with confidence. There is nothing like that HIV has a longer window period. Don't get confused with unauthorized information.
You need no further testing for HIV. Your symptoms are not related to HIV.
Dr S.Murugan


reliable lab . I did not able to overcome my fear sir I really appreciate and thankfull to your words and experience.
Your rashes are not due to HIV
Detailed Answer:
Hi,
Welcome back.
LAL PATH LAB is one of the good labs in XXXXXXX and highly reliable one. I had never come across any case of HIV 2 with a undetectable serology or without any serologic evidence. Regarding HIV 2 RNA PCR I had very limited experience. MY cases of HIV 2 were diagnosed only with antibody ELISA or Tridot test. I had come across many patients on line with negative HIV 2 RNA PCR and remain free from any HIV infection for months after.
I had seen the pictures sent by you. They are not related to HIV infection.
Dr S.Murugan


Your fever is unlikely due to HIV infection
Detailed Answer:
Hi,
Welcome back.
Please stop getting materials from on line. Rare and odd possibilities are to be forgotten.
Early manifestations of HIV can occur within 4-6 weeks and is self limiting and not all will get this acute infection stage (only with 50-70%). Your post exposure, especially with the condom broken incident, it had gone more than 52 days. It is unlikely due to HIV infection.
Even though HIV RNA PCR can not detect the presence of an infection if the viral load is below 900, in early stages of infection the viral load will be high also with HIV 2 infection. So missing the chance of getting detected is quite unusual. You fever can be due to various other reasons and your physician will diagnose the same and you will be alright soon. Forget about HIV.
Dr S.Murugan


sir my pcr RNA + my 4 genth antibody test on 50th are reliable? Do I need any further testing . 50 days is little shorter than 8 week which cover 90-95% infection. Sir I really messed I always calculated the probility of having HIV 2 infection. I read the symptoms online and fear that I have all of them till date. I have spend a lot of money and time .
4th generation DUO HIV test can rule out HIV 2 by 90 days after exposure.
Detailed Answer:
HI,
Welcome back.
Seroconversion 3 months after the exposure can occur only in extreme situations like people taking immunosuppressive drugs. Otherwise seroconversion will not extend beyond 3 months in normal situation both for HIV and 2 infection. 4th generation HIV DUO test by 50th day after exposure can be taken as confirmatory as far as HIV 1 infection is concerned and not for HIV 2 infection. 4th generation test can rule out HIV 2 by 12 weeks after the exposure.
So you wait till another 40 days and repeat the test and rule out HIV 2 infection if you have any suspicion about your HIV 2 RNA PCR test. Anybody can get illness in an unprecedented situation.
Dr S.Murugan


Your symptoms are not related to HIV.
Detailed Answer:
Hi,
Welcome back to HCM.
Paracetamol and Combiflam alone may not be enough to tackle your fever. You may need antibiotics. Consult your physician about this.
I will consider the RNA PCR for HIV 2 infection 45 days after the exposure as final and reliable. HIV 2 is a rarest possibility and that also ruled out by the HIV 2 PCR test.
Your antibody 1&2 test also can be expected to come as nonreactive if you repeat the same after 3 months.
DR S.Murugan

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