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Is Celebrex Safe To Use Despite Allergic Reactions To Sulfa Drugs?

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Posted on Wed, 22 Nov 2023
Question: can a patient that is allergic to sulfa drugs use celebrex
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Answered by Dr. Panagiotis Zografakis (42 minutes later)
Brief Answer:
yes

Detailed Answer:
Hello,

celecoxib does have some chemical parts in common with sulfa drugs so in theory there are some risk. Current data are conflicting though and there is not enough evidence that an allergic reaction will occur for non-antibacterials. Just keep in mind that you never know whether an allergic reaction will occur until you take the drug. The same applies even if you've uneventfully taken the drug in the past.
Also have a look at this: https://www.ncbi.nlm.nih.gov/pubmed/0000
This article concludes with "there is no documentation for cross-reactivity between sulfonamide antimicrobials and other sulfonamide medications, such as celecoxib".

So it seems to be safe to use celecoxib and your doctor seems to agree with that. If you had a very serious reaction though (like allergic shock) then I would have looked for alternatives. Current literature seems to clear non-antibacterials regarding cross-reactivity with anti-bacterials but since this drug can be substituted why take the risk?

I hope you find my comments helpful!
Kind Regards!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3814 Questions

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Is Celebrex Safe To Use Despite Allergic Reactions To Sulfa Drugs?

Brief Answer: yes Detailed Answer: Hello, celecoxib does have some chemical parts in common with sulfa drugs so in theory there are some risk. Current data are conflicting though and there is not enough evidence that an allergic reaction will occur for non-antibacterials. Just keep in mind that you never know whether an allergic reaction will occur until you take the drug. The same applies even if you've uneventfully taken the drug in the past. Also have a look at this: https://www.ncbi.nlm.nih.gov/pubmed/0000 This article concludes with "there is no documentation for cross-reactivity between sulfonamide antimicrobials and other sulfonamide medications, such as celecoxib". So it seems to be safe to use celecoxib and your doctor seems to agree with that. If you had a very serious reaction though (like allergic shock) then I would have looked for alternatives. Current literature seems to clear non-antibacterials regarding cross-reactivity with anti-bacterials but since this drug can be substituted why take the risk? I hope you find my comments helpful! Kind Regards!