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Is HIV-1/-2 Antibody Screening Test Done 3 Months Post Exposure Conclusive?

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Posted on Mon, 4 Jan 2016
Question: I had a hiv 1 and 2 antibody (includes p24) test on 8 th sept 2015 and 10 December 2015. After an exposure on 4th XXXXXXX 2015. Both the test came back non reactive with a value of 0.08. Are the tests conclusive .
doctor
Answered by Dr. Tushar Kanti Biswas (33 minutes later)
Brief Answer:
HIV 1 & 2 tests

Detailed Answer:
Hi,

Thank you for your query. I can understand your concerns.
Antibodies to HIV generally appear in the circulation 3-12 weeks following infection.If your supposed exposure is on 04.6.2015 -then by now 3 months have passed. So for all practical purpose you are negative for HIV infection with those negative results.

Both 1 & 2 are enzyme immuno assay (EIA) tests and these are more than 99.5 % sensitive. You have undergone 4th generation test which combine detection of antibody to HIV 1 & 2 and p24 antigen capture assay. These test are usually reported as positive, negative (non-reactor ) and indeterminate. The tests are repeated or further test like Western blot is asked for when the test is indeterminate.

In a nutshell, for all practical purposes, you have negative results. Therefore you need not worry. Be assured about your HIV negative status.

If possible can you upload the test reports of 8.9.15 and 10.12.15 for perusal as reference ranges differ from Lab to Lab.

Regards

Dr. T.K. Biswas M.D. XXXXXXX

Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Tushar Kanti Biswas (3 hours later)
The test used was CMIA , reference range was less than one NON REACTIVE , greater than or equal to one PROVISIONALLY REACTIVE. MY VALUE WAS 0.08. The exposure was on the night of 4 th XXXXXXX 2015 and my last test was done on 10 dec 2015. Can this test be considered as 6 month test.
doctor
Answered by Dr. Tushar Kanti Biswas (5 hours later)
Brief Answer:
CMIA at 12 and 24 weeks post-exposure

Detailed Answer:
HIV-DUO Serum by CMIA (4th generation)is conclusive at 6 weeks. You have undergone repeated tests on 8.9.15 (12 weeks) and 10.12.15 (more than 24 weeks) following exposure.
CMIA provides more accurate results earlier than the ELISA test.
Since your value (0.08) is much below the reference range of 1 (considered reactive) and that too after a period of 6 months, you are not carrying HIV infection anyway.
The initial test is negative at 12 weeks; retesting should be performed
only as clinically indicated. However you have undergone re-testing (you can consider as 6 month test) which has also come negative;hence HIV infection is ruled out.
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Tushar Kanti Biswas (1 hour later)
Dear doctor pls tell me the date for 6 month testing. On your answer I concludeD that it was not 6 month mark . Was the test done by me not after 6 months . Why are you saying you can consider it as 6 months. Don't you think it to be conclusive.
doctor
Answered by Dr. Tushar Kanti Biswas (1 hour later)
Brief Answer:
HIV testing repeatedly negative

Detailed Answer:
Your second test on 10.12.15 is a six month test,whatever you can call it..In fact there is no such test as 6 month test for HIV.There is no requirement of any further test for HIV in your case.Rest assured.
Note: Get personalized answers to your HIV related queries You can choose to talk face to face with your doctor. Book a Video Call now.

Above answer was peer-reviewed by : Dr. Yogesh D
doctor
Answered by
Dr.
Dr. Tushar Kanti Biswas

Internal Medicine Specialist

Practicing since :1975

Answered : 1920 Questions

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Is HIV-1/-2 Antibody Screening Test Done 3 Months Post Exposure Conclusive?

Brief Answer: HIV 1 & 2 tests Detailed Answer: Hi, Thank you for your query. I can understand your concerns. Antibodies to HIV generally appear in the circulation 3-12 weeks following infection.If your supposed exposure is on 04.6.2015 -then by now 3 months have passed. So for all practical purpose you are negative for HIV infection with those negative results. Both 1 & 2 are enzyme immuno assay (EIA) tests and these are more than 99.5 % sensitive. You have undergone 4th generation test which combine detection of antibody to HIV 1 & 2 and p24 antigen capture assay. These test are usually reported as positive, negative (non-reactor ) and indeterminate. The tests are repeated or further test like Western blot is asked for when the test is indeterminate. In a nutshell, for all practical purposes, you have negative results. Therefore you need not worry. Be assured about your HIV negative status. If possible can you upload the test reports of 8.9.15 and 10.12.15 for perusal as reference ranges differ from Lab to Lab. Regards Dr. T.K. Biswas M.D. XXXXXXX