Is Melatonin Safe To Be Taken With Citalopram?

Posted on Mon, 21 Nov 2016

Question: Is Melatonin and/or Valerian safe to take with citalopram and trifluoperazine?

Thank you.

Answered by Dr. Shafi Ullah Khan (2 hours later)

Brief Answer:
Interactions found

Detailed Answer:
Thank you for asking

I read your question and i understand your concern. Valerian and citalopram both increase sedation so not wise to use together. Also trifluoperazine and melatonin together interacts and cause excessive sedation. So i would not advise more than two medications at a time. Citalopram and trifluoperazine are alone enough and should work. If the others two are needed, dose should be kep to the minimum and be prescribed by the doctor and let them adjust the doses accordingly.

I hope it helps. Take good care of yourself and dont forget to close the discussion please.

Regards
Khan

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Shafi Ullah Khan (16 hours later)

Thank you for your response to my question. I was under the impression that citalopram is an anti depressant. Can an anti depressant increase sedation? Or does it have the opposite effect?

Thank you,
XXXX

Answered by Dr. Shafi Ullah Khan (7 hours later)

Brief Answer:
Pharmacodynamic synergism

Detailed Answer:
Thank you for getting back to me

yes its antidepressant and alone it does not cause much sedation. But when you take it in combination mentioned above, both drugs potentiate each others effect and increase sedation and drowsiness. A phenomenon called pharmacodynamic synergism. So should be avoided.

I hope it helps.
Regards
Khan

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Shafi Ullah Khan (1 hour later)

Thank you. I learned something new.
Take care,
XXXX

Answered by Dr. Shafi Ullah Khan (22 hours later)

Brief Answer:
:)

Detailed Answer:
You are welcome XXXX.

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar