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Is Stematil Safe With Sertraline?

Posted on Mon, 18 May 2015

Question: I'm on 150 mg of Sertraline a day am also on stemetil for vomiting is this safe my doctor says it's ok my pharmacist says avoid

Answered by Dr. Dr. Muhammad Sareer Khalil (8 minutes later)

Brief Answer:
Stematil is safe with sertraline

Detailed Answer:
Hello and Welcome

I appreciate your concern

Sertraline will increase the level of Stematil (pro chlorperazine ) by affecting hepatic metabolism. Though the interaction is minor and you can safely take stematil with prochlorperazine.

Wishing you best of health

Thanks

Please consult your doctor before deciding on any further course of action.

Dr. M.S. Khalil

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj

Follow up: Dr. Dr. Muhammad Sareer Khalil (1 hour later)

I was told about something called seratoin syndrome does that not apply? Also the internet say to avoid

Answered by Dr. Dr. Muhammad Sareer Khalil (9 minutes later)

Brief Answer:
The interaction doesnt lead to serotonin syndrome

Detailed Answer:
Hello again,

Respected madam sertraline is an SSRI ( selective serotonin reuptake inhibitor ). Serotonin syndrome is a drug interaction of SSRIs with drugs like MAO inhibitors, Tricyclic anti depressants, meperidine , dextromethorphan.

There is a minor interaction of sertraline with stematil and based on a number of clinical interactions, concomitant use of both does not lead to serotonin syndrome. You can use both safely.

Hope this makes it more clear.

Please consult your doctor before taking any medication.

Thanks.

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Above answer was peer-reviewed by : Dr. Raju A.T