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Is VDRL Titre Value Of 1:16 After Adequate Treatment A Cause For Concern?

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Posted on Wed, 20 Jan 2016
Question: Hi doctor, I had syphilis 11 months ago from the titres vdrl 1:64 after I take the medicine last 2 months now my titres fall down to 1:16, but last week I went to lab again and found out that the titres is still 1:16, why the titres didn't fall again become lower?
Thx
doctor
Answered by Dr. Dr. Kakkar (22 minutes later)
Brief Answer:
VDRL titres fall 4 fold every 3 months.

Detailed Answer:
Hello. Thank you for writing to us

I have read your query and I am glad to help you with your concern.

VDRL titres fall 4-fold every 3 months after adequate treatment for syphilis i.e if the titre was 1:64 before treatment, it should be 1:16 at 3 months mark after treatment and 1:4 at 6 months mark, from treatment.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (17 minutes later)
Thx for the answer. Doctor last week I also check the TORCH test and found anti toxo IgG positive with Kons 205 , toxo IgM negative kons 0,21; anti rubella IgG positive with kons 84, rubella IgM negative; anti CMV IgG positive with kons 60, CMV IgM negative; anti HSV2 IgG negative and anti HSV2 IgM negative.
Need your opinion, thx
doctor
Answered by Dr. Dr. Kakkar (6 hours later)
Brief Answer:
Common viral infections and the significance of positive tests

Detailed Answer:
Hi.

Toxoplasma, cytomegalovirus and rubella are common viral infections and majority of the general population would be having antibodies (including me, just as you) to these infections as most individuals would already have been exposed to the infecing organisms at some point earlt in childhood or adolescence. Antibodies once developed can be detected in circulating blood for the rest of the lives. These infections are asymptomatic and do not cause symptoms in immunocompetent individuals.
Regarding the type of antibody, presence of IgG type antibodies against toxoplasma, cmv and rubella indicates that these are older/ past infections whereas IgM type is usually an indicator of recent infection and it can be seen that you have detectable IgG antibodies against toxoplasma, cytomegalovirus and rubella which indicates a past/ previous infection whereas IgM is negative as expected. (IgM type of antibody is detectable in blood immediately after recent/ new infection e.g within the first 1-2 months of acquiring the infections and thereafter it is replaced by IgG type of antibody, which persists for life!).
Negative IgG and IgM for hsv indicates that you have never been exposed to herpes virus type 2 ever. Hsv type 2 is the cause for genital herpes and infection is usually acquired by close/ sexual contact with an infected sexual partner

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (2 hours later)
How about with the kons, is that number normal ? What caused that number is very high? I heard that CMV is caused our eyes can't see clearly / blur and now that happens to me
doctor
Answered by Dr. Dr. Kakkar (8 hours later)
Brief Answer:
Your test results are Ok

Detailed Answer:
Hi.

These titres are ok. CMV causes retinitis i.e ocular involvement in immunocompromised individuals e.g HIV / AIDS patients, and not in people with an intact immune system.
Your ocular symptoms could be due to another unrelated cause and I suggest that you visit an ophthalmologist for a check up.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (3 hours later)
Doctor, actually I'm afraid that I am suffering by HIV, I don't brave enough to have a test for this, what is the sympthoms for the HIV person after suffering more than 6 months?
doctor
Answered by Dr. Dr. Kakkar (9 hours later)
Brief Answer:
Symptoms vary according to the stage of disease

Detailed Answer:
Hi

Symptoms mainly depend on the stage of disease. They may vary from fever; weight loss; recurrent or prolonged diarrhea; recurrent infections--skin and pneumonia; oral candidiasis; reactivation of herpes etc. In early stages there may be no symptoms at all and the infection is only detected on blood tests.
Wht do you think that you may have Hiv?Is there is possible history of exposure to HiV?

Regards
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Dr. Kakkar

Dermatologist

Practicing since :2002

Answered : 9610 Questions

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Is VDRL Titre Value Of 1:16 After Adequate Treatment A Cause For Concern?

Brief Answer: VDRL titres fall 4 fold every 3 months. Detailed Answer: Hello. Thank you for writing to us I have read your query and I am glad to help you with your concern. VDRL titres fall 4-fold every 3 months after adequate treatment for syphilis i.e if the titre was 1:64 before treatment, it should be 1:16 at 3 months mark after treatment and 1:4 at 6 months mark, from treatment. Regards