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Is Chemotherapy Advisable When Having Liver Metastasis?

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Posted on Mon, 12 Jan 2015
Question: My father age 80yrs opted upon for ca sigmoid colon on 13/11/14 as resection and anastomosis.
He is a diebetic.He has liver mets also.
He tolerated operation very well.But his GC is not improving.He has 13 kg wt loss.Can I think about chemotherapy for him?
doctor
Answered by Dr. K. Harish (4 hours later)
Brief Answer:
Only if feasible

Detailed Answer:
Hi,

Thanks for the query. I understand your concern.

Your father has liver metastasis. He would ideally require chemotherapy.
Remember: remedy should not be worse than disease.

But you should always weigh the benefits with the risks. This has to be jointly decided by your father, the family and the treating doctor. Have a detailed discussion with your father and amongst yourselves. Frame a set of questions including what would happen if he does not receive chemotherapy at all and what are the potential side effects of chemotherapy. Discuss these issues with the doctor and then take a final decision. Once you are done with a decision, (either way) you have to make up your mind that the decision is ABSOLUTELY right.

The problem here is you would feel guilty if chemotherapy were not to be administered and he deteriorates(you would feel he would have benefited from chemo). You would also feel guilty if chemo results in severe side effects (you would feel he was better off without chemo). To have that confidence, you need to talk to him (although it may be a very sensitive issue). If you go by his decision after deliberation, you would definitely have that confidence without guilt.

Both decisions are OK. You could have guilt if the decision does not go your way. Hence take your father into confidence.
Above answer was peer-reviewed by : Dr. Ashwin Bhandari
doctor
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Follow up: Dr. K. Harish (8 hours later)
Resp sir,
I want an expert opinion.
My father has dibetes and high B P.
Now he cannot walk or sit on comod without assistance.He has lost 13 kg of wt postoperativly as I mentioned erlier.
You are saying same thing as my general surgeon is saying.
Now he is taking food.He is walking with assistance.I want to know by an expert who has seen many ca sigmoid colon patients with liver mets with old age of 80 yrs.Can I improve the GENERAL CONDITION of my father by giving chemo or will it deteriorate due to chemo?What would be prognosis with or without chemo?What would happen to him with or without chemo?
Please do not give answer as a counselor but give answer as an expert onchophysian.
doctor
Answered by Dr. K. Harish (16 hours later)
Brief Answer:
It has to be your decision

Detailed Answer:
Hi,

I understand your concern.

The effect of chemotherapy can be assessed only after administration. You have to take a call on whether patient is better off without or with chemotherapy. This answer can be given only by YOU (or patients near and dear). The next best person would be your treating surgeon and oncologist.

You have to understand that we are not astrologers to say if you take chemo this is the result and if you do not take chemo this is the result. Medical science is NOT exact science. There are many variables. The suggestion of chemotherapy is based on usefulness in patients with nodal disease. If you ask me whether it will help every patient with nodal disease, the answer would be NO.


Above answer was peer-reviewed by : Dr. Ashwin Bhandari
doctor
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Follow up: Dr. K. Harish (6 hours later)
I am already confused.PET scan report shows mets in liver and some lymph nodes in abdomen.One simple question is prognosis with and without chemo?
doctor
Answered by Dr. K. Harish (16 minutes later)
Brief Answer:
Your decision

Detailed Answer:
Patient is 80 years old and probably not in the best of health.

Patient has nodal and liver metastates.

Technically requires chemotherapy. But with age and general condition against him, it would be tricky. You should make a decision based on the following
1. survival benefit with chemotherapy
2. quality of life improvement with chemotherapy
3. prevention of potential complications with chemotherapy
4. patient's ability to withstand the therapy

Patient has stage IV disease. The idea of treatment (by any means including chemotherapy) is palliative (meaning prevention or alleviation of suffering). However, in colon cancer with liver spread the prognosis is better compared to other diseases with liver spread.

Not a very accurate prediction, but chemotherapy is unlikely to offer survival benefit (more so because further surgery in him like liver resection if required would not be possible). Chemotherapy is expected to improve his quality of life. Whether it actually does that or not is speculative and differs from person to person.

I think you should have a reasonable idea to make a decision with this information.
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. K. Harish (18 minutes later)
How many days he will survive without chemo?His all blood reports are almost ok.Give tentative idea.I know nobody can give exact answer.Thank you.
doctor
Answered by Dr. K. Harish (8 hours later)
Brief Answer:
less than two years

Detailed Answer:
Nobody can predict survival. But generally they survive for less than two years. If disease progresses rapidly could be a matter of weeks/months or can prolong to more than two years, if progression is slow. (the disease progression varies from person to person). Survival for a few months to a year is likely in most cases.
Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Shanthi.E
doctor
Answered by
Dr.
Dr. K. Harish

Oncologist, Surgical

Practicing since :1986

Answered : 59 Questions

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Is Chemotherapy Advisable When Having Liver Metastasis?

Brief Answer: Only if feasible Detailed Answer: Hi, Thanks for the query. I understand your concern. Your father has liver metastasis. He would ideally require chemotherapy. Remember: remedy should not be worse than disease. But you should always weigh the benefits with the risks. This has to be jointly decided by your father, the family and the treating doctor. Have a detailed discussion with your father and amongst yourselves. Frame a set of questions including what would happen if he does not receive chemotherapy at all and what are the potential side effects of chemotherapy. Discuss these issues with the doctor and then take a final decision. Once you are done with a decision, (either way) you have to make up your mind that the decision is ABSOLUTELY right. The problem here is you would feel guilty if chemotherapy were not to be administered and he deteriorates(you would feel he would have benefited from chemo). You would also feel guilty if chemo results in severe side effects (you would feel he was better off without chemo). To have that confidence, you need to talk to him (although it may be a very sensitive issue). If you go by his decision after deliberation, you would definitely have that confidence without guilt. Both decisions are OK. You could have guilt if the decision does not go your way. Hence take your father into confidence.