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Is Inhalation Of Glutathione Effective For Lung Disorders?

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Posted on Thu, 29 May 2014
Question: Does anyone have experience with inhaled Glutathione and Lung Disorders? Specifically the buffered kind of Glutathione. Straight Glutathione can be acidic.
doctor
Answered by Dr. Shafi Ullah Khan (9 hours later)
Brief Answer:
Glutathion may worsen sarcoidosis

Detailed Answer:
Thank you for asking!
Glutathion is gamma-L-glutamyl-L-cysteinylglycine, GSH, L-glutathione, N-(N-L-gamma-glutamyl-L-cysteinyl)glycin.. and is from Cardiovascular, Herbals; Oncology, Herbals; Urology, Herbals classes and is Powerful antioxidant; co-factor in Phase I hepatic detoxification; involved in synthesis of DNA & proteins, amino acid transport, enzyme activation, immune system function
used for Male infertility (IM use), atherosclerosis (IV, PO use), cancers, chemotherapy adjunct (IM, IV use), diabetes (IV use), immunostimulant, liver diseases, lung diseases (inhaled use), memory loss, Parkinson's disease (IV, PO use) and has proved some benefits.
In inhaled doses 0f 600 mg twice a day is recommended for lung disorders. But you should keep it in mind that inhaled use of it leads to bronchospasm and is no way indicated for asthma and thus it may worsen the Pulmonary complaints (dyspnea on exertion, cough, chest pain, and hemoptysis) in your sarcoidosis case and thus it is not wise to use unless prescribed by your pulmonologist.
You used steroids for your sarcoidosis, why dont you try non steroids management.
Noncorticosteroid agents include the following:

Methotrexate (MTX) has been a successful alternative to prednisone
Chloroquine and hydroxychloroquine have been used for cutaneous lesions, hypercalcemia, neurologic sarcoidosis, and bone lesions
Chloroquine has been found effective for acute and maintenance treatment of chronic pulmonary sarcoidosis
Cyclophosphamide has been rarely used with modest success as a steroid-sparing treatment in patients with refractory sarcoidosis
Azathioprine is best used as a steroid-sparing agent
Chlorambucil may be beneficial in patients with progressive disease unresponsive to corticosteroids or when corticosteroids are contraindicated
Cyclosporine may be of limited benefit in skin sarcoidosis or in progressive sarcoid resistant to conventional therapy
Infliximab and thalidomide have been used for refractory sarcoidosis, particularly for cutaneous disease, as well as for the long-term management of extrapulmonary sarcoidosis
Infliximab appears to be an effective treatment for patients with systemic manifestations such as lupus pernio, uveitis, hepatic sarcoidosis, and neurosarcoidosis
Discuss the options with your pulmonologist.And if your pulmonary functions are below this threshold
Forced vital capacity below 50% predicted
Forced expiratory volume in 1 second below 40% predicted
then you need a lung transplant. Get to your pulmonologist and let them decide what is best for you.
I hope it helps. DOnt forget to close the discussion please.
May the odds be ever in your favour.
Regards
S Khan


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shafi Ullah Khan (1 hour later)
Dr. XXXXXXX I see you know alot about it. I am impressed. But I have a follow up question. Normally Glutathione preperations are acidic. The one I have is cut with baking soda. It comes in supplement capsules that you drop into 10 ml of water in your inhaler. Being that it is buffered, do you think it still has the bronchospasm problem?Oh and I still have 97% oxygen levels. My lungs are fairly healthy, and I appreciate all the information on alternatives to steroids. This doc poisoned me on the steroids. I got every fricken side effect. Broke my leg, and gained all the weight, cholestrol and blood sugar, and slight loss of eye sight. So thank you for the alternatives and I am getting a new pulmonologist shortly.
doctor
Answered by Dr. Shafi Ullah Khan (9 hours later)
Brief Answer:
Medium does not change the effect

Detailed Answer:
Thank you for getting back to me!
Glutathione has its effects irrespective of the medium. Inhaled glutathione needs no acidic medium , it needs this medium of alkalinity and that is why it is diluted in 10 ml of water as that is required for nebulized inhaled product. Bronchospasm effect is of glutathione. The medium of acidity or alkalinity is not going to effect that. Its good to hear that you have good pulmonary functions. And yes the steroids are hazardous when it comes to steroids use. Acidic glutathione is for oral use and alkaline glutathione is for inhaled use. The medium does not change the effect of glutathione.
Hope it helps. Discuss any medicine before taking it with your doctor as they say every drug is a poison and every poison is a drug.
Take care and dont forget to close the discussion please.
Regards
S Khan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Shafi Ullah Khan

General & Family Physician

Practicing since :2012

Answered : 3613 Questions

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Is Inhalation Of Glutathione Effective For Lung Disorders?

Brief Answer: Glutathion may worsen sarcoidosis Detailed Answer: Thank you for asking! Glutathion is gamma-L-glutamyl-L-cysteinylglycine, GSH, L-glutathione, N-(N-L-gamma-glutamyl-L-cysteinyl)glycin.. and is from Cardiovascular, Herbals; Oncology, Herbals; Urology, Herbals classes and is Powerful antioxidant; co-factor in Phase I hepatic detoxification; involved in synthesis of DNA & proteins, amino acid transport, enzyme activation, immune system function used for Male infertility (IM use), atherosclerosis (IV, PO use), cancers, chemotherapy adjunct (IM, IV use), diabetes (IV use), immunostimulant, liver diseases, lung diseases (inhaled use), memory loss, Parkinson's disease (IV, PO use) and has proved some benefits. In inhaled doses 0f 600 mg twice a day is recommended for lung disorders. But you should keep it in mind that inhaled use of it leads to bronchospasm and is no way indicated for asthma and thus it may worsen the Pulmonary complaints (dyspnea on exertion, cough, chest pain, and hemoptysis) in your sarcoidosis case and thus it is not wise to use unless prescribed by your pulmonologist. You used steroids for your sarcoidosis, why dont you try non steroids management. Noncorticosteroid agents include the following: Methotrexate (MTX) has been a successful alternative to prednisone Chloroquine and hydroxychloroquine have been used for cutaneous lesions, hypercalcemia, neurologic sarcoidosis, and bone lesions Chloroquine has been found effective for acute and maintenance treatment of chronic pulmonary sarcoidosis Cyclophosphamide has been rarely used with modest success as a steroid-sparing treatment in patients with refractory sarcoidosis Azathioprine is best used as a steroid-sparing agent Chlorambucil may be beneficial in patients with progressive disease unresponsive to corticosteroids or when corticosteroids are contraindicated Cyclosporine may be of limited benefit in skin sarcoidosis or in progressive sarcoid resistant to conventional therapy Infliximab and thalidomide have been used for refractory sarcoidosis, particularly for cutaneous disease, as well as for the long-term management of extrapulmonary sarcoidosis Infliximab appears to be an effective treatment for patients with systemic manifestations such as lupus pernio, uveitis, hepatic sarcoidosis, and neurosarcoidosis Discuss the options with your pulmonologist.And if your pulmonary functions are below this threshold Forced vital capacity below 50% predicted Forced expiratory volume in 1 second below 40% predicted then you need a lung transplant. Get to your pulmonologist and let them decide what is best for you. I hope it helps. DOnt forget to close the discussion please. May the odds be ever in your favour. Regards S Khan