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Is Intake Of Myo-Inositol And Metformin During Pregnancy A Cause For Concern?

Posted on Fri, 26 May 2017

Question: Hello i am 30weeks preg diagnosed wth gestational diabeties. I am on 600 mg myo inositol and 500 mg metformin once a day. Want to know if these medicines are safe during pregnancy. And does they effect aminiotic fluid levels.

Answered by Dr. Deepti Verma (1 hour later)

Brief Answer:
Safe in pregnancy

Detailed Answer:
Hi dear,
I have gone through your question and understand the concerns.
Gestational diabetes should ideally be managed by diabetic diet and if not controlled by diet, then insulin should be given.
Myoinositol is given in pregnancy to reduce the risk of gestational diabetes.
It is not used for treatment of this condition.
Metformin is given for treatment of diabetes, and can be given in pregnancy.
Both drugs are safe in pregnancy and have minimal effect on the amniotic fluid.
However, I will suggest you to consult your treating doctor about the rationale of starting these drugs, and discuss about diabetic diet and insulin.
Hope you found the answer helpful.
Regards
Dr Deepti Verma
OBGYN
Maternal and fetal medicine specialist

Above answer was peer-reviewed by : Dr. Kampana

Follow up: Dr. Deepti Verma (26 minutes later)

My sugar is not very high .... thats y she doesnt want to start insulin.... my fluid level was 20 cm 10 days ago and now 10.5 .... is it possible... the only medicines i started during this period is myoinositol and metformin.Or is it possible ultrasound has miscalculated AFI.
My doctor said 20 is high for AFI.... if i was having this high fluid i could not have walk properly and felt very heavy and streched. Is this true

Answered by Dr. Deepti Verma (17 hours later)

Brief Answer:
Seems to be miscalculation

Detailed Answer:
Hi dear,
Its ok to not to start insulin, however you should follow and have diabetic diet.
AFI is not decreased by these two drugs.
The previous AFI of 20 seems to be miscalculated.
This high AFI causes breathing and walking discomfort.
I will suggest you to get a follow up scan after a week to check the AFI.
Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Remy Koshy

Follow up: Dr. Deepti Verma (1 hour later)

I have already got a follow up scan done it says my AFI is 10.5 ... so thats y i was concerned do these medicines lower aminiotic fluid levels....should i continue myoinositol.... or i should go for metformin alone

Answered by Dr. Deepti Verma (1 hour later)

Brief Answer:
Only metformin

Detailed Answer:
Hi dear,
I am advising a follow up scan after this scan telling the AFI of 10.5, so that it can be assessed that the AFI is actually decreasing.
I will suggest you to continue with the metformin alone, as myoinositol do not help much in decreasing the blood sugar levels.
Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Nagamani Ng

Follow up: Dr. Deepti Verma (1 hour later)

Thank you i was super confused... i was not able to decide should i continue myoinositol. Can u tell me one more thing is it normal to feel drowsy in third trimester and having leg cramps.

Answered by Dr. Deepti Verma (45 minutes later)

Brief Answer:
Happy to help

Detailed Answer:
Hi dear,
I am happy to have helped you.
Yes, it is normal to have leg cramps and drowsiness in third trimester.
Avoid standing for prolonged time, and take plenty of fluids.
You can get back to me anytime for health queries by asking a direct question to me on the health care magic portal.
Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Nagamani Ng