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Is It Advisable To Take Allopurinol For A Flare Up Of Gout While On Hydrochlorothiazide?

Posted on Fri, 11 Mar 2022

Question: my name is XXXXXXX I currently take hydrochlorothiazide 25mg I recently had a flare up of gout and I am taking allopurinol 100 mg is it ok to take both medicine? the hctz I take is for blood pressure. I take the hctz at night and allopurinol in morning. I am concern with interaction.

Answered by Dr. Ilir Sharka (54 minutes later)

Brief Answer:
I recommend stopping Hydrochlorothiazide.

Detailed Answer:

Hello,

I would explain that Hydrochlorothiazide leads to increased uric acid levels, as a common adverse effect.

For this reason, I would recommend switching to another antihypertensive drug like amlodipine or losartan and avoid Hydrochlorothiazide.

You should discuss with your doctor on this issue.

Hope you will find this answer helpful!
Regards,
Dr. Iliri

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar