Sign-in to Ask A Doctor - 24x7
OR
Sign in with Google
Is It Safe To Decrease The Dosage Of Solian From 100mg To 50mg?
Question: Dear Dr. Sheppe,
My name is XXXXXXX i am on Lexapro 15 mg, Klonopin 3 mg, Solian 50 mg and Keppra 1000mg.
I am now with Solian 50 mg for 8 days, instead of Solian 100 mg. I don't understand why, but ome things are worse and other are now better in my "fixations", it's very difficult because i have at the same time the two "images" (some better, some worse). I would like if it's in a certain way normal since there is less synergistic activity between Solian and Lexapro, as far as i understand. I would like to know also if things can go better soon or it's necessary to change something.
Thanks, XXXXXXX
My name is XXXXXXX i am on Lexapro 15 mg, Klonopin 3 mg, Solian 50 mg and Keppra 1000mg.
I am now with Solian 50 mg for 8 days, instead of Solian 100 mg. I don't understand why, but ome things are worse and other are now better in my "fixations", it's very difficult because i have at the same time the two "images" (some better, some worse). I would like if it's in a certain way normal since there is less synergistic activity between Solian and Lexapro, as far as i understand. I would like to know also if things can go better soon or it's necessary to change something.
Thanks, XXXXXXX
Brief Answer:
Consultation
Detailed Answer:
Hello XXXXXXX it's always good to talk with you. Thanks again for asking a direct question.
It seems for you the transition from Solian 100mg to 50mg is having mixed results so far. Can you tell me in more detail exactly what is better, and what is worse? You are absolutely right, there is a big less synergism currently with the Solian and Lexapro. I will say that it is still early in the transition. Eight days is enough to see a change in side effects, but not soon enough to see the full BENEFITS of the change, which will happen anywhere from 2-6 weeks. Tell me how things are different so far and we can talk about how to make the transition more smooth. I do believe this change to 50mg is a good idea for you, and that things will get better with time on this dosage.
Dr. Sheppe
Consultation
Detailed Answer:
Hello XXXXXXX it's always good to talk with you. Thanks again for asking a direct question.
It seems for you the transition from Solian 100mg to 50mg is having mixed results so far. Can you tell me in more detail exactly what is better, and what is worse? You are absolutely right, there is a big less synergism currently with the Solian and Lexapro. I will say that it is still early in the transition. Eight days is enough to see a change in side effects, but not soon enough to see the full BENEFITS of the change, which will happen anywhere from 2-6 weeks. Tell me how things are different so far and we can talk about how to make the transition more smooth. I do believe this change to 50mg is a good idea for you, and that things will get better with time on this dosage.
Dr. Sheppe
Above answer was peer-reviewed by :
Dr. Raju A.T
Dear Dr. Sheppe,
Thanks a lot for your answer. The matter is just the fixation with windows of cars, as always (with the change from 100 mg to 50 mg of Solian i feel also a little bit more tired, but nothing important, and i feel also with more appetite): it's incredible, but first, this fixation changes during the day (some times according also to Klonopin, i guess because effect of this med in cathecolamines, including the dopaminergic effect of Solian) and to things like the distance of the window, the light of the day and the form of the window. Some moments are better, some moments are worse, but it's very unstable and i have to say, selective. I hope this description helps.
Thanks, XXXXXXX
Thanks a lot for your answer. The matter is just the fixation with windows of cars, as always (with the change from 100 mg to 50 mg of Solian i feel also a little bit more tired, but nothing important, and i feel also with more appetite): it's incredible, but first, this fixation changes during the day (some times according also to Klonopin, i guess because effect of this med in cathecolamines, including the dopaminergic effect of Solian) and to things like the distance of the window, the light of the day and the form of the window. Some moments are better, some moments are worse, but it's very unstable and i have to say, selective. I hope this description helps.
Thanks, XXXXXXX
Brief Answer:
Followup
Detailed Answer:
Thanks, this is very helpful indeed.
I think this particular fixation will be improved in the long term with the lower dose of Solian because of its partial agonist actions on dopamine receptors. However, sometimes during short-term changes there are paradoxical opposite reactions as receptors are upregulated or downregulated in order to achieve their new steady-state. I would give it another week or so, and reassess at that time, as your dopamine receptors will be more stably at their new levels by that time.
Dr. Sheppe
XXXX
Followup
Detailed Answer:
Thanks, this is very helpful indeed.
I think this particular fixation will be improved in the long term with the lower dose of Solian because of its partial agonist actions on dopamine receptors. However, sometimes during short-term changes there are paradoxical opposite reactions as receptors are upregulated or downregulated in order to achieve their new steady-state. I would give it another week or so, and reassess at that time, as your dopamine receptors will be more stably at their new levels by that time.
Dr. Sheppe
XXXX
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Raju A.T
Answered by
Get personalised answers from verified doctor in minutes across 80+ specialties
