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Is It Safe To Have 5mg Pregnenolone Every Day?

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Posted on Mon, 10 Nov 2014
Question: My blood work showed low pregnenolone of less than 10mg. I had a oophorectomy 2 years ago and surgery for hormone negative breast cancer. My doctor wants me to take pregnenolone supplements. Is a low dosage of 5mg safe?
doctor
Answered by Dr. Richa Agarwal (45 minutes later)
Brief Answer:
Yes, low dose may be safe.

Detailed Answer:
Hi,

Thanks for writing to us about it.

I can see your concern here.

First and foremost important thing is that every medication has its own side effects.

Pregnelone is a hormonal supplement which converts in estrogen in our body.

As a breast cancer in your case was hormone negative, but pregnalone use increase estrogen level in the body and increase chances of breast malignant neoplastic disease.

After oopherectomy it is a quite useful hormonal supplement.

Thus in your scenario you can use it in low doses as cyclic therapy, but keep watch on its side effect due to its estrogenic effect.

Hope I have answered your query if you have further questions I will be happy to assist you.

Good luck.
Regards
Dr.Richa
Above answer was peer-reviewed by : Dr. Bhagyalaxmi Nalaparaju
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Follow up: Dr. Richa Agarwal (11 hours later)
What do you mean by cyclic cycle?
doctor
Answered by Dr. Richa Agarwal (4 hours later)
Brief Answer:
See the description below.

Detailed Answer:
Hi,

Nice to hear from you all again.

Pregnalonone is a hormonal supplement and you can not take hormone therapy regularly, you should call for breaks between therapy that is called hormonal holiday.

It is called cyclic therapy means use of low dosage of hormone for short period of time, then break for a few weeks then again start the drug.

It will lessen the side effect of drug and decrease the chances of adrenal damage.

Hope your doubt is clear now, feel free to ask more.

Good luck.
Regards
Dr.Richa
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.

Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Richa Agarwal

OB & GYN Specialist

Practicing since :1999

Answered : 4026 Questions

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Is It Safe To Have 5mg Pregnenolone Every Day?

Brief Answer: Yes, low dose may be safe. Detailed Answer: Hi, Thanks for writing to us about it. I can see your concern here. First and foremost important thing is that every medication has its own side effects. Pregnelone is a hormonal supplement which converts in estrogen in our body. As a breast cancer in your case was hormone negative, but pregnalone use increase estrogen level in the body and increase chances of breast malignant neoplastic disease. After oopherectomy it is a quite useful hormonal supplement. Thus in your scenario you can use it in low doses as cyclic therapy, but keep watch on its side effect due to its estrogenic effect. Hope I have answered your query if you have further questions I will be happy to assist you. Good luck. Regards Dr.Richa