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Is It Safe To Take Elavil At Bedtime And Effexor-XR In The Morning?
Question: Is it safe to take 50 mg of amitripylene ( Elavil) at bedtime and 37.5 mg venlafaxine XR in the morning?
Brief Answer:
yes, it is safe
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
Amitripylene , a tricyclic antidepressant dose-PO 75 to 150 mg/day given in evening or at bedtime because of sedative effects.
Venlafaxine , an antidepressant of the serotonin-norepinephrine reuptake inhibitor
PO 75 mg/day administered in single dose either in morning or evening at approximately same time each day.
Since your prescribing doctor has recommended these doses and they are well within dose limits, there is no reason why it won't be safe.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
yes, it is safe
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
Amitripylene , a tricyclic antidepressant dose-PO 75 to 150 mg/day given in evening or at bedtime because of sedative effects.
Venlafaxine , an antidepressant of the serotonin-norepinephrine reuptake inhibitor
PO 75 mg/day administered in single dose either in morning or evening at approximately same time each day.
Since your prescribing doctor has recommended these doses and they are well within dose limits, there is no reason why it won't be safe.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Above answer was peer-reviewed by :
Dr. Shanthi.E
My primary concern was my body producing too much serotonin by taking both these medications together from my understanding there is a negative interaction between these medications that 'could' lead to serotonin syndrome ?
Is there a specific period of time or maximum daily mg intake I should be aware
of?
Thank You
Is there a specific period of time or maximum daily mg intake I should be aware
of?
Thank You
Brief Answer:
Serotinin syndrome
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
A “serotinin syndrome,” can occur when venlafaxine (serotonin-norepinephrine reuptake inhibitor) is combined with drugs like Sibutramine, Sumatriptan, Trazodone.
Venlafaxine has no drug interaction with tricyclic antidepressant like Amitriptyline. .
Amitriptyline may cause hyperpyretic crises with MAOIs.
The maximum dosage of individual drugs are as I have mentioned in my earlier reply. Also, your Psychiatrist would be aware of this. Even then both the drugs are well within their prescribed dose limits. Hence, it is not a cause of concern for you.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Serotinin syndrome
Detailed Answer:
Hi,
Thank you for your query. I can understand your concerns.
A “serotinin syndrome,” can occur when venlafaxine (serotonin-norepinephrine reuptake inhibitor) is combined with drugs like Sibutramine, Sumatriptan, Trazodone.
Venlafaxine has no drug interaction with tricyclic antidepressant like Amitriptyline. .
Amitriptyline may cause hyperpyretic crises with MAOIs.
The maximum dosage of individual drugs are as I have mentioned in my earlier reply. Also, your Psychiatrist would be aware of this. Even then both the drugs are well within their prescribed dose limits. Hence, it is not a cause of concern for you.
Regards
Dr. T.K. Biswas M.D. XXXXXXX
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Shanthi.E
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