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Is It Safe To Take Leflunomide And Warfarin Together?

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Posted on Fri, 16 Jun 2023
Question: What is the affect of Leflunomide on Warfarin? Is it safe to take the two together?
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Answered by Dr. Bonnie Berger-Durnbaugh (37 minutes later)
Brief Answer:
Ok, but see your primary doctor check if INR is changing.

Detailed Answer:

Hello,

The answer to your question is that Leflunomide can affect Warfarin's effects and can increase or decrease the INR levels. It is not absolutely contraindicated to take the two together, but the INR should be monitored more closely when taking both.

If you have been prescribed these medications from different doctors, be sure that your primary doctor, who checks your INR, knows about this. You may need to have your INR checked in 2-3 days after starting the leflunomide.

Hope I have answered your query.

Regards,
Dr. Bonnie Berger-Durnbaugh, General & Family Physician
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3133 Questions

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Is It Safe To Take Leflunomide And Warfarin Together?

Brief Answer: Ok, but see your primary doctor check if INR is changing. Detailed Answer: Hello, The answer to your question is that Leflunomide can affect Warfarin's effects and can increase or decrease the INR levels. It is not absolutely contraindicated to take the two together, but the INR should be monitored more closely when taking both. If you have been prescribed these medications from different doctors, be sure that your primary doctor, who checks your INR, knows about this. You may need to have your INR checked in 2-3 days after starting the leflunomide. Hope I have answered your query. Regards, Dr. Bonnie Berger-Durnbaugh, General & Family Physician