Is Pregnancy Still Possible Despite Two Cycles Of Hormone Therapy Without Successfully Conceiving?

Posted on Fri, 30 Apr 2021

Question: Hi, my wife is undergoing hormone therapy for planned pregnancy and it has been two cycles taking letoval, ovabless,Metformin & Estradiol dosages on particular cycle day as directed by the doctor.
First cycle she was given all the meds except Metformin, follicular US showed no obvious follicle, the cycle ended with one week delayed mens & was given meprate to initiate it as HPK was negative.
Second cycle she was given Metformin along with all the other meds, follicular US on 8 day showed follicle of 7 & 8mm EM .8, but on 13 day which was suppose to be ovulation day she Bleed with no abdominal pain lasted for 4 days as same as periods. Now doc has given her Susten 200, for initiation of regular cycle.
What had happened? Can she still be pregnant, did she had withdrawal bleeding? Shall we continue with the treatment?please help!!

Answered by Dr. Soumya (16 minutes later)

Brief Answer:
Start HMG Injections in next cycle

Detailed Answer:
Hi,

I understand your concerns.

Following is my reply:

1) It is strange to see no dominant follicles developed in the ovaries and she had mid cycle bleeding.

2) Mid cycle bleeding is due to variation of progesterone hormone and probably untimely withdrawal effect. This may not repeat again.

3) Request your doctor to add gonadotropins (HMG) injections in next cycle which will help in getting dominant follicle and improve follicle size soon.

4) This will help you to ovulate and try for pregnancy. She will get pregnant. Dont worry. Please continue treatment with an IVF centre preferably.

Let me knwo if you need anymore help.

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Soumya (30 minutes later)

So there’s no chance of her being pregnant rite now? As her ultrasound showed no follicles but mild free fluid on 17th cycle day i.e after the bleeding.

Answered by Dr. Soumya (14 hours later)

Brief Answer:
Less chances of pregnancy

Detailed Answer:
Hi,

There is chances of pregnancy as there is free fluid but less chances. This shows possibly the follicle is ovulated. It would have been much certain if dominant follicles were spotted.

Midcycle bleeding destroys endometrium which is important to have implantation and pregnancy. This brings down chances of pregnancy.

Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar