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Is There Any Interaction Between Lexapro And Klonopin?

Posted on Wed, 28 Jan 2015

Question: I am on Klonopin 2 mg, Lexapro 50 mg, Keppra 1500 mg and Solian 100 mg (amisulpride). I feel some kind of interaction between Lexapro and Klonopin, but i am not sure. I need a good plasma concentration of Lexapro for an OCD symptom (sometimes it seems resolved at 90 %), but i would like to know if for example because of 3A4 enzyme or for some other reason Klonopin can lower Lexapro concentrations or on the contrary.
Thanks beforehand

Answered by Dr. Shubham Mehta (1 hour later)

Brief Answer:
NO interaction between lexapro and klonopn

Detailed Answer:
Hello
Welcome to HCM.

You are taking treatment for OCD.

Regarding lexapro, i would like to tell you that most studies have shown that escitalopram has negligible inhibitory effects on CYP isoenzymes, suggesting that escitalopram is unlikely to cause clinically significant drug-drug interactions.

For this reason, escitalopram is considered quintessential SSRI and is the preferable drug for most anxiety (includes OCD) and depressive disorder.

I donnt think there is any drug interaction between lexapro and klonopin which can alter therapeutic response.

Hope this helps.

Any further queries are welcome.

Thanks.
Dr. Shubham Mehta, M.D.(Psychiatry).

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Shubham Mehta (1 hour later)

Dear Dr. Mehta,
Thanks very much for your answer.
I would like to know finally if Keppra has any effect in Lexapro's plasma concentrations, since i've been told by some doctors that there is no effect and by some others that there is an effect.
Thanks beforehand, XXXXXXX

Answered by Dr. Shubham Mehta (22 minutes later)

Brief Answer:
no effect of keppra on lexapro.

Detailed Answer:
Dear XXXXXXX

There is no effect of keppra on plasma concentration of lexapro even when keppra is given in higher doses.

Hope this answers your query.

Feel free to ask further.

Kindly close the discussion if you have no more queries and give your valuable feedback.

If you wish, you can also ask a direct query at your convenience.

Thanks.
Dr. Shubham Mehta.

Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Raju A.T