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Is There Increased Risk Of Cancer From Abdominal CT Radiation Exposure For Someone Carrying A BRCA 2 Mutation?

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Posted on Mon, 1 Apr 2024
Question: any data available or studies done on increased risk of cancer from abdominal ct radiation exposure for someone carrying a BRCA 2 mutation to a normal?
doctor
Answered by Dr. Monish De (33 minutes later)
Brief Answer:
Hazard Ratio of 2.86

Detailed Answer:
Hi

CT radiation exposure for someone carrying BRCA2 mutation has a hazard ratio (HR) of 2.86.

It means the risk of death is 2.86 times more than to a normal person who has not been exposed to radiation

Regards

Dr Monish De

Oncologist
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Monish De (44 minutes later)
relative to a normal individual without the mutation is that a greatly increased risk?

in other words. if a persons risk of cancer is 1/10 without the radiation does that make it 2.86/10?

does it matter which part of the body is affected, breast vs pancreas, prostate, etc?
doctor
Answered by Dr. Monish De (10 minutes later)
Brief Answer:
With radiation cancer risk increases to 2.86/10.

Detailed Answer:
Hi

Yes it is a greatly increased risk relative to normal individual without mutation.

With abdominal CT radiation cancer risk increases to 2.86/10.

Pancreas and prostate is affected the most.

Regards

Dr Monish De

Oncologist
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Monish De (22 minutes later)
particular stats on pancreatic cancer for a brca2 who received about 40msv of radiaton.

i know an estimate is all that can be done and nothing is guaranteed
doctor
Answered by Dr. Monish De (5 minutes later)
Brief Answer:
Development of Pancreatic cancer increases by 25%

Detailed Answer:

Hi

Stats on development of pancreatic cancer for brca2 mutation who received 40 msv of radiation is 25%


Regards

Dr Monish De

Oncologist
Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Monish De

Oncologist

Practicing since :2004

Answered : 2229 Questions

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Is There Increased Risk Of Cancer From Abdominal CT Radiation Exposure For Someone Carrying A BRCA 2 Mutation?

Brief Answer: Hazard Ratio of 2.86 Detailed Answer: Hi CT radiation exposure for someone carrying BRCA2 mutation has a hazard ratio (HR) of 2.86. It means the risk of death is 2.86 times more than to a normal person who has not been exposed to radiation Regards Dr Monish De Oncologist