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Is Type-1 Diabetes A T-cell-mediated Autoimmune Disease?

Posted on Mon, 21 Aug 2017

Question: How is the T cell involved in the destruction of auto immune in diabetes type 1 for children 7 years old. thank you very much doctor

Answered by Dr. Mirjeta Guni (57 minutes later)

Brief Answer:
About autoimmune distruction in type 1 Diabetes:

Detailed Answer:
Hello again,
I can understand your concern regarding to a 7 year old child diagnosed with type 1 Diabetes.
Well, now it is approved that Type 1 diabetes is a T cell-mediated autoimmune disease.
As you may know, Beta cells in the pancreas produce insulin. In type 1 diabetes, another type of white blood cells known as B lymphocytes work to activate the autoreactive T cells, or T lymphocytes, to destroy the beta cells in the pancreas.
The damaged cells cannot carry glucose to cells causing it to build up in the blood, leading to type 1 diabetes.
This is a summarized mechanism, but if you need a detailed one i can attach some studies that explain it in details.

Kind regards,
Dr.Mirjeta

Above answer was peer-reviewed by : Dr. Kampana

Follow up: Dr. Mirjeta Guni (23 minutes later)

yes please that would be helpful if you can attached it might help me better understand. thank you so much

Answered by Dr. Mirjeta Guni (1 hour later)

Brief Answer:
Articles giving information regarding to type 1 Diabetes:

Detailed Answer:
Here are some links giving detailed information regarding type 1 Diabetes, mechanism:
https://www.academic.oup.com/qjmed/article/98/8/547/0000/Immunology-of-type-1-diabetes
http://www.pnas.org/content/102/51/18425.full.pdf
http://www.diabetesandenvironment.org/home/mech/betacells
http://www.medscape.com/viewarticle/449087
http://www.medscape.com/viewarticle/862258

Best wishes,
Dr.Mirjeta

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Above answer was peer-reviewed by : Dr. Kampana