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My HBa2 Is 5.8 ( Beta-thalassemia Trait ) And My
Question: My HBa2 is 5.8 (Beta-thalassemia trait) and my husband HBa2 is 4....we have daughter whose HBa2 is 3.6 (Delta Beta Thalassaemia Trait.)... we dont have any issues still now....we are planning for 2 nd...plz suggest for any test is required or how much safety is there.
Brief Answer:
Molecular testing to detect Hb mutation for your family is suggested
Detailed Answer:
Hello,
Thanks for posting your query on Ask A Doctor forum.
The haemoglobin electrophoresis reports give a clear picture that you and your husband have elevated HbA2 which is suggestive of thalassemia trait.
These results should be followed by molecular tests for detecting mutations in haemoglobin chain.
You have had a one year old child with 20% fetal haemoglobin which is high as compared to normal range for age.
In addition, there is elevated level of HbA2 also.
Your child also needs to undergo molecular test.
I would suggest you to get the molecular test done before planning second pregnancy.
In addition, subsequent pregnancies should be tested for any mutation during pre-natal period.
Since, both you and your husband have thalassemia trait, precautions in the form of counselling and pre-natal testing should be done to avoid any pregnancy with thalassemia major or intermedia.
Thanks and take care
Dr Shailja Puri
Molecular testing to detect Hb mutation for your family is suggested
Detailed Answer:
Hello,
Thanks for posting your query on Ask A Doctor forum.
The haemoglobin electrophoresis reports give a clear picture that you and your husband have elevated HbA2 which is suggestive of thalassemia trait.
These results should be followed by molecular tests for detecting mutations in haemoglobin chain.
You have had a one year old child with 20% fetal haemoglobin which is high as compared to normal range for age.
In addition, there is elevated level of HbA2 also.
Your child also needs to undergo molecular test.
I would suggest you to get the molecular test done before planning second pregnancy.
In addition, subsequent pregnancies should be tested for any mutation during pre-natal period.
Since, both you and your husband have thalassemia trait, precautions in the form of counselling and pre-natal testing should be done to avoid any pregnancy with thalassemia major or intermedia.
Thanks and take care
Dr Shailja Puri
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Raju A.T
Answered by
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