My Multiple Myeloma FISH Test Results Were All Negative Except

Posted on Sat, 29 Feb 2020

Question: My Multiple Myeloma FISH Test results were all negative except for IgH/CCDN1. What does a positive IgH/CCDN1 mean? Does it have a favorable prognosis?
Thank you

Answered by Dr. Indranil Ghosh (2 hours later)

Brief Answer:
It has no impact on prognosis

Detailed Answer:
Hi

IgH/CCND1 has neutral impact on prognosis, which means other cytogenetic changes will dictate prognosis.

As in your case, others are negative, you should have better prognosis.

Hope this helps.

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Indranil Ghosh (2 hours later)

So the positive IgH/CCDN1 means I have Multiple Myeloma?

Answered by Dr. Indranil Ghosh (2 hours later)

Brief Answer:
It's not a diagnostic test

Detailed Answer:
This result doesn't favour nor refute the diagnosis of myeloma. It's for prognostication.

It doesn't indicate any unfavorable outcome.

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Indranil Ghosh (45 hours later)

What do I have?
Thank you!

Answered by Dr. Indranil Ghosh (3 hours later)

Brief Answer:
Monoclonal gammopathy

Detailed Answer:
These results suggest monoclonal gammopathy. It could be MGUS if bone marrow plasma cells less than 10% and no anemia, high calcium, kidney or bone damage.

If bone marrow plasma cells higher than 10%, it may be smoldering myeloma.

If anemia, high calcium, kidney or bone damage are present, then it becomes multiple myeloma.

MGUS or smoldering myeloma can progress to myeloma, the latter at much higher rate.

Hope this helps.
Regards

Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Prasad