My Liver Enzymes Are Going Up Alt 421, 659, 683.

Posted on Fri, 9 Nov 2018

Question: My liver enzymes are going up alt 421, 659, 683. no hepatitis. No problem on ultrasound. no fever or loss of appetite. Pain in upper left abdomen. No Advil etc, Prior pancreatic duct surgery. No gall bladder. changed from Valsartan to Losartan about 1 month ago. Was on nitrofurantoin until 10 days ago. why still going up
Son has serious Chrones disease. I have repeated pain in abdomen of moderated level.

Answered by Dr. Ramesh Kumar (1 hour later)

Brief Answer:
can be due to nitrofurantoin.

Detailed Answer:
Hello and thanks for choosing "Ask A Doctor" service for your query,
Have seen your details and i appreciate your concerns,
Work of liver in body is to metabolize things.Same applies with medicines specially antibiotics.When ever a person is on antibiotics liver cells are damaged hence the enzymes stored in them are released into blood causing elevation of liver functions.
As ultrasound is normal i would suggest you to get a serology test done i.e HBsAG and HCV if they are normal take sylimarin milk of thistle for 15 days along with herbal tablets LIV52 once daily(available online) they would help the liver to rejenuvate.
Take a high carbohydrate based diet easy to digest.
Avoid to much fat and meat.

Repeat the tests after 15 days(make sure no antibiotics are taken in between).
Follow ups are welcome!
Regards!

Above answer was peer-reviewed by : Dr. Nagamani Ng

Follow up: Dr. Ramesh Kumar (7 hours later)

How long does it take for nitrofurantoin to stop affecting the liver enzymes? About how many days? Could the change from valsartin to losartin be the cause of increase of enzymes?

Answered by Dr. Ramesh Kumar (36 minutes later)

Brief Answer:
Follow up.

Detailed Answer:
Hi again,
1)About 4 to 6 weeks).
2)No very unlikely.
Thanks!

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Above answer was peer-reviewed by : Dr. Yogesh D