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My Platelet Has Always Been High In The Range Of
Question: My platelet has always been high in the range of 600-700 x 10"9/L. My other blood count is within normal range as of today.
1. 10 years ago I had two BCR/ABL test (peripheral blood) to rule out CML, one test came back positive the other negative. Which test should I believe?
2. I had a JAK2+ test drawn with peripheral blood and it came back positive, based on this the doctor diagnosed me with Essential Thrombocystosis, does the presence of JAK2+ gene automatically rule out CML ?
3. I don't take any medication at all, would it be possible for me to stay in Chronic phase of CML for 10 years?
1. 10 years ago I had two BCR/ABL test (peripheral blood) to rule out CML, one test came back positive the other negative. Which test should I believe?
2. I had a JAK2+ test drawn with peripheral blood and it came back positive, based on this the doctor diagnosed me with Essential Thrombocystosis, does the presence of JAK2+ gene automatically rule out CML ?
3. I don't take any medication at all, would it be possible for me to stay in Chronic phase of CML for 10 years?
Brief Answer:
Yes jak2 and bcr abl are not seen together
Detailed Answer:
Hi
Thanks for your query.
Since you have only elevated platelets for 10 yrs then CML becomes extremely unlikely. Also bcr abl and jak2 are not seen together in one patient.
Hence I think you are bcr abl negative and essential thrombocytosis is the correct diagnosis.
Hope this helps.
Regards
Yes jak2 and bcr abl are not seen together
Detailed Answer:
Hi
Thanks for your query.
Since you have only elevated platelets for 10 yrs then CML becomes extremely unlikely. Also bcr abl and jak2 are not seen together in one patient.
Hence I think you are bcr abl negative and essential thrombocytosis is the correct diagnosis.
Hope this helps.
Regards
Above answer was peer-reviewed by :
Dr. Yogesh D
Thank You for the response
I have read that Leukemia can occur without Leukocytosis, in this case how would one detect the Leukemia?
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/542919
I have read that Leukemia can occur without Leukocytosis, in this case how would one detect the Leukemia?
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/542919
Brief Answer:
Yes but not in CML
Detailed Answer:
Very unlikely in CML, especially without treatment for 10 years. This can happen in acute leukemias, and easily detected by bone marrow exam.
Hence it's extremely unlikely to be CML.
Regards
Yes but not in CML
Detailed Answer:
Very unlikely in CML, especially without treatment for 10 years. This can happen in acute leukemias, and easily detected by bone marrow exam.
Hence it's extremely unlikely to be CML.
Regards
Above answer was peer-reviewed by :
Dr. Arnab Banerjee
Last question:
The two tests for BCR/ABL were "Multiplex-RT PCR" and "Qualitative Reverse Transcriptase-PCR"
Are these two the same? If not which one is more sensitive in detecting BCR/ABL
Many Thanks
The two tests for BCR/ABL were "Multiplex-RT PCR" and "Qualitative Reverse Transcriptase-PCR"
Are these two the same? If not which one is more sensitive in detecting BCR/ABL
Many Thanks
Brief Answer:
Multiplex more sensitive
Detailed Answer:
But lot depends on the kit used and the expertise of the lab.
Regards
Multiplex more sensitive
Detailed Answer:
But lot depends on the kit used and the expertise of the lab.
Regards
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Arnab Banerjee
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