My Protein Eletrophoresis Results Continue To Slowly Decrease. My Gamma

Posted on Sun, 5 Jul 2020

Question: My protein eletrophoresis results continue to slowly decrease. My gamma globulin has been at .7 for over a year, my Immunoglobulin M has gone from a 44 to a 38 over the last year. My Kappa serum is 14.4 Lambda is 8.5, with a ratio of 1.69 my kappa urine is 1.24, lambda urine is 0.07 and the ratio is 17.71 do i need to be concerned?

Answered by Dr. Ramesh Kumar (51 minutes later)

Brief Answer:
Need few details sir.

Detailed Answer:
Hello and thank you for choosing "Ask a Doctor" service for your query,
Have seen your details my dear and I appreciate your concerns,
I just need one more detail before answering the query dear that why is the test done.Is is a part of regular check up? Which usually it is not or there is some pathological condition associated?
Secondly this change is over a period of one year?
waiting!
Regards.

Above answer was peer-reviewed by : Dr. Yogesh D

Follow up: Dr. Ramesh Kumar (6 hours later)

I am 47 years of age. My H1C is 5.7. I I have been seeing a rheumatologist for about 15 years now. I was told last year that I have the genetic marker for Ankylosing Spondilitus. I do not have the inflamation markers for it. I have lots of tendon issues in my hands, elbows, and shoulders and groin. I have a standing weekly appointment with a chiropractor becasuse I can't seem to keep things in place. I have been diagnosed with fibromyalgia. I had a complete hystorectomy 5 years ago due to endometriosis. I had two tumors in the smooth muscle of my upper stomach that had to be removed about 5 years ago. My doctor has been checking my Kappa/Lambda serum levels for a while now, at least a year, maybe longer. This last time she ordered the urine test also. I was told due to some of the medications that I am on they want to keep an eye on my kidney and liver

Answered by Dr. Ramesh Kumar (16 hours later)

Brief Answer:
Follow up.

Detailed Answer:
Hello again,
I personally don't feel that's a problem because usually the patients of spondolitis are kept in doses of immunosuppressants.
The immunoglobulin may be effected in such cases also as they are also produced by bone marrow.
However an exact opinion on this one can be given by a Rheumatologist.
However it's a part of treatment (As any immunosuppressant therapy would effect it).
Thanks!

Note: For further follow up on digestive issues share your reports here and Click here.

Above answer was peer-reviewed by : Dr. Vaishalee Punj