Brief Answer:
No, GNRH development is not affected by androgens.

Detailed Answer:
Good Day!

GnRh development is not affected by testosterone or exogenous anabolic steroids. That being said as you may already know testosterone will inhibit the release of GnRh as a negative feedback mechanism. Usually and more often than not, levels of GnRh will go back to normal after stopping exogenous testosterone/steroids use without any permanent damage/consequence.

You may be suffering from hypogonadism (low testosterone) if you feel weak, depressed, you feel that your testes is small than what it should be, secondary male characteristics did not develop (little or no pubic hair, high pitched voice, small penis etc). If you feel you have the above mentioned symptoms i would suggest seeing a urologist or an endocrinologist to have hormonal testing done.

Best of Luck.

---

Brief Answer:
No, testosterone doesn't develop central puberty.

Detailed Answer:
Hi,

Thanks for your query.

Testosterone therapy can induce precocious puberty but not usually on short term therapy. Androgen therapy will not trigger the central level to produce GNRH to produce more testosterone but will be the opposite due to the negative feedback mechanism. So my answer is No, testosterone doesn't develop central puberty at the central level.

Thank You.

---

Brief Answer:
No there will be no long term effect on Gnrh.

Detailed Answer:
I believe there will be no programming effect or will alter the balance of Gnrh after a short term androgen use during puberty. The body will find its homeostasis after the negative feedback subsides and testosterone has a very short half-life (2-4 hours). So testosterone will be cleared by the body very fast and Gnrh will then regulate the release of testosterone.

I hope I have answered your question. Thank You and good day.


Yours truly,


Manuel See IV, MD DPBU

---