Results Are Normal For Factor Eight Clotting Disorder . Within

Posted on Thu, 5 Sep 2019

Question: Results are normal for factor eight clotting disorder. Within the comment Section it states results are suggestive of a specific or nonspecific inhibitor. then it suggest possible lupus. if all the testing for lupus is normal what would be the next step to test for inhibitors?

Follow up: Dr. Bhagyesh V. Patel (0 minute later)

Results are normal for factor eight clotting disorder. Within the comment Section it states results are suggestive of a specific or nonspecific inhibitor. then it suggest possible lupus. if all the testing for lupus is normal what would be the next step to test for inhibitors?

Answered by Dr. Bhagyesh V. Patel (7 hours later)

Brief Answer:
multi system involvement as metabolic, hematology and others.

Detailed Answer:
Hello and welcome to Ask A Doctor services.
I have read your query with attached reports.

* The condition can be from various issues of multi system involvement as
metabolic pathway, hematology, immunology and others.
Comments for the next step would be best judged over further
information.

Kindly provide me further details so that I can answer your query completely.

1. Onset with progress details of the condition.
2. Photo pic of current skin lesion appearance in follow up as an attachment.
3. Is there bruise development after minor trauma ?
4. Any other reports available for evaluation if any ?

Awaiting for your response.
Dr Bhagyesh ( MS consultant surgeon )

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Answered by Dr. Bhagyesh V. Patel (0 minute later)

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Bhagyesh V. Patel (13 hours later)

I have a mildly elevated D-dimer with no evidence of a clot. livedo pattern on legs. legs feel heavy, fatigued, joint pain and easy exhaustion. adult onset. there is a familiar history of a hereditary disorder. After 13 years of testing has yet to be able to be identified. Have been tested extensively for autoimmune disorders. None have been found.

Follow up: Dr. Bhagyesh V. Patel (0 minute later)

Answered by Dr. Bhagyesh V. Patel (48 minutes later)

Brief Answer:
follow up.

Detailed Answer:
Hi,
Thank you for the clinical photo attached.

* Sorry to say but there are many of the clinical conditions involving the immune
system, coagulation parameters which are under evaluation and many of
them go undiagnosed for decades.

When the evaluation of extensive workup for an autoimmune disorder is non-conclusive, means the entity is rarest of rare.

I would like to know about the status and report if any so far as a skin biopsy or vessel biopsy is concerned.

Thanks.
Regards

Above answer was peer-reviewed by : Dr. Arnab Banerjee

Answered by Dr. Bhagyesh V. Patel (0 minute later)

Above answer was peer-reviewed by : Dr. Arnab Banerjee

Follow up: Dr. Bhagyesh V. Patel (8 hours later)

Rarest of the rare unfortunately is probably the category that we will be in. My father and his two brothers Suffer from an unattainable disease. Multiple genetic testing has not we build an answer. They have a cute onset of symptoms with a recovery. ataxia, word of Asia, visual field disturbances, short-term memory loss, severe headache. after the acute attack they do recover some but never fully. He has two sisters that seem to take the route that I am taking. One sister was diagnosed with MS then change to neurological condition of unknown origin, the other sister was diagnosed with atypical ALS. my father and I both have an elevated D dimer. he has an Elevated adamts13 activity. Protein electrophoresis,c-z Electrophorese, Factor five and factor eight, Porphyria all normal testing. normal kidney and liver function test, normal iron normal antithrombin three activity.

Follow up: Dr. Bhagyesh V. Patel (0 minute later)

Answered by Dr. Bhagyesh V. Patel (42 minutes later)

Brief Answer:
follow up .

Detailed Answer:
Hi
Welcome for follow up.

* I can understand your mental status with chronic condition without
diagnosis.

Still, advanced molecular science has lot more to explore against many mysterious medical facts of such diseases which can not be diagnosed and nor cured.

Your case is a research topic and time can only reveal some of the positive findings or hope.

Let us hope for the best.
Be Positive and stay happy from inside to make physical findings less heavier than it is actual.

Regards.

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Answered by Dr. Bhagyesh V. Patel (0 minute later)

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Answered by Dr. Bhagyesh V. Patel (2 days later)

Brief Answer:
von Willebrand factor or Gp1b receptor of platelets problem.

Detailed Answer:
Hello
Welcome for follow up.

* An elevated Ristocetin co factor indicate possible issues with von Willebrand
factor from endothelial cells or Gp1b receptor of platelets.

This issue need additional antibody work up for the same and same should be discussed with treating hematologist.

Thanks.

Above answer was peer-reviewed by : Dr. Nagamani Ng

Answered by Dr. Bhagyesh V. Patel (0 minute later)

Above answer was peer-reviewed by : Dr. Nagamani Ng

Follow up: Dr. Bhagyesh V. Patel (5 minutes later)

New testing came in elevated Ristocetin Cofactor and elevated Adamts13(greater than 10%25). Normal factor v

Follow up: Dr. Bhagyesh V. Patel (0 minute later)

New testing came in elevated Ristocetin Cofactor and elevated Adamts13(greater than 10%25). Normal factor v

Follow up: Dr. Bhagyesh V. Patel (16 hours later)

Thank you so much for all your help. It is greatly appreciated! trying to navigate the healthcare system in knowing what direction to go for a lay person is very challenging. I have done my due diligence diligence with and attempt to learn as much as I can for possible diagnosis is. To have someone help point me in the direction goes beyond and mir thank you.

Follow up: Dr. Bhagyesh V. Patel (0 minute later)

Answered by Dr. Bhagyesh V. Patel (8 hours later)

Brief Answer:
follow up .

Detailed Answer:
Thanks for the follow up and feedback.
Would like to know further ware about of the condition as per your convenience.

Wish you best health for always.
Regards.

Above answer was peer-reviewed by : Dr. Yogesh D