Should I Discontinue Use Of Naproxen I Am Being Tested For Cadmium Poisoning?
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Detailed Answer:
Hello,
I read your question carefully and I understand your concern. Also, thank you for the link provided regarding cadmium toxicity.
Chronic cadmium exposure can cause different clinical manifestations. Cadmium has half life of 30 years and it accumulates in the body mainly in the liver, kidney and pancreas. It is eliminated very slowly mainly through the kidneys.
Cadmium toxicity has different clinical manifestations depending cadmium compounds accumulated. Therefore, any suspected signs or symptoms of Cadmium toxicity should be confirmed by laboratory tests.
Kidney function tests should be done as the cadmium mostly affects the kidneys. You should have creatinine, blood urea nitrogen, protein, and glucose tests. Furthermore, complete blood count, liver function tests, and DEXA (for osteoposrosis) should be done. If the kidney function and other tests suggest cadmium toxicity urinary cadmium or beta-2-microglobulin should be checked to confirm cadmium toxicity. Blood cadmium level is not useful, as it shows recent exposure. If the cadmium toxicity is confirmed you should be treated with chelating agents such as EDTA, that binds and increases urinary elimination of cadmium.
If your kidney function is not normal you should not take naproxen or any othe non-steroidal anti-inflammatory drugs. You can safely take paracetamol. Additionally, pyridoxine may also increase the toxic effects of cadmium. Before stopping any of the medicines you should be laboratory confirmed of cadmium toxicity.
I hope the above information will be helpful for you. Please, feel free to ask me if there is anything else you need to know.
Thank you
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Detailed Answer:
Hi,
You are most welcome.
Thank you for the follow-up questions.
Cadmium toxicity is not related to your hobby. Acute cadmium toxicity is highly unlikely.
It is likely you had exposure in Kona Coffee farm. Measuring cadmium levels in the blood shows recent exposure. In recent exposure the high concentration of cadmium is still present in the blood. But after certain time the cadmium is taken up by organs and gradually accumulate in organs-mostly in kidney and liver. At this time blood cadmium test is not helpful. Urinary cadmium test or beta-2-microglobulin test shows chronic cadmium toxicity even you had exposure many years ago. But it is really difficult to say how long you had cadmium in your body. Hair or nail cadmium can be studied to measure time of exposure or accumulation time but that requires sophisticated laboratory equipment.
Hope the information is helpful. Wishing you good health.
Thank you.
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Detailed Answer:
Hi,
The most commonly heavy metals from contaminated soil or waters besides cadmium are arsenic, copper and lead. But the biological half-time of these metals are much shorter than cadmium. As I explained in my previous answer cadmium has about 30 years of biological half life. In order to completely eliminate cadmium from the body it takes about 60 years without an intervention. Other heavy metals have relatively short biological half life. After the exposure it takes maximum 10 years for cobalt, or just 2 months for lead to clear from the body. Other metals are not much concern. Even you had an exposure to other heavy metals or toxins in the past, they already eliminated from your body.
Hope this helps. Please do not hesitate to let me know if you have any questions.
Sincerely