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Spouse Had Recent MRI For Severe Dizziness , Double Vision
Question: Spouse had Recent MRI for severe dizziness, double vision and ataxia. Non specific and periventricular white matter FLAIR/T2 hypersensitivities.
They called it a negative MRI for stoke. And most Likley symptoms are vestibular in nature. My question is could these findings represent PML? She is on rituximab, azathioprine and corticosteroids for polymyositis. She tested positive for the JC virus with a relatively high tiger prior to treatment with rituximab. Just don’t want to miss anything.
They called it a negative MRI for stoke. And most Likley symptoms are vestibular in nature. My question is could these findings represent PML? She is on rituximab, azathioprine and corticosteroids for polymyositis. She tested positive for the JC virus with a relatively high tiger prior to treatment with rituximab. Just don’t want to miss anything.
Brief Answer:
Unfortunately PML is a possibility in this case.
Detailed Answer:
Hello and welcome to "Ask a Doctor " service.
I have read your query and here is my advice.
PML is possible in persons who have a weakened immune system and infected with JC virus.
So, I must say that in your spouse's case, this is possible since she is using immunosuppressive drugs, resulted positive for JC virus and there were white matter changes in the MRI.
The necessary tests to evaluate correctly PML and to exclude it are test of cerebrospinal fluid for JC virus DNA and brain ( lesion ) biopsy that can be drawn under stereotactic guide.
Discuss with your spouse's Neurologist for these issues.
Hope you found the answer helpful.
Let me know if I can assist you further.
Unfortunately PML is a possibility in this case.
Detailed Answer:
Hello and welcome to "Ask a Doctor " service.
I have read your query and here is my advice.
PML is possible in persons who have a weakened immune system and infected with JC virus.
So, I must say that in your spouse's case, this is possible since she is using immunosuppressive drugs, resulted positive for JC virus and there were white matter changes in the MRI.
The necessary tests to evaluate correctly PML and to exclude it are test of cerebrospinal fluid for JC virus DNA and brain ( lesion ) biopsy that can be drawn under stereotactic guide.
Discuss with your spouse's Neurologist for these issues.
Hope you found the answer helpful.
Let me know if I can assist you further.
Note: For further information on diet changes to reduce allergy symptoms or to boost your immunity, Ask here.
Above answer was peer-reviewed by :
Dr. Raju A.T
Answered by
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