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Suggest Dosage For Temozolomide For A Patient With Brain Cancer
Question: Is there information that you can please provide on outcomes since 2012 of new trials of the brain cancer drug Temozolomide involving changing the dosage, cycle, and in combination with and without radiation. Thank you. XXXXXXX XXXX - YYYY@YYYY
What is the customary lead time needed by your medical professionals to provide a comprehensive answer regarding a specialty question?
Please just kindly advise, when I should begin watching my email, to look for a reply. Thank you.
What is the customary lead time needed by your medical professionals to provide a comprehensive answer regarding a specialty question?
Please just kindly advise, when I should begin watching my email, to look for a reply. Thank you.
Brief Answer:
Dosage guidelines mentioned
Detailed Answer:
Thanks for asking on HealthcareMagic.
I have gone carefully through your query. The following information should be useful for you:
* Adjuvant therapy for Grade II (low-grade infiltrative astrocytomas, oligodendroglioma, mixed gliomas) brain cancer includes temozolomide 150-200 mg/sq.m/day orally on days 1-5 of a 28-day cycle for six to eight cycles.
* Recurrences or progressive, low-grade disease (previously untreated): Temozolomide 75 mg/m 2 orally daily on days 1-21 or 150-200 mg/sq.m orally on days 1-5 of a 28-d cycle until disease progression or for a maximum of 24 cycles.
* For Grade III (anaplastic astrocytoma or oligoastrocytoma): The standard of care is surgical resection followed by External Beam Radiation Therapy (EBRT) (60 Gy in 30-35 fractions) and adjuvant temozolomide, 75 mg/sq.m/day orally on days 1-42, usually 1-1.5 hours before radiation.
* For Post–radiation therapy: Temozolomide needs to be continued at higher doses of 150-200 mg/sq.m/day orally on days 1-5 every 28 day.
* For Grade IV (glioblastoma): The standard of care is surgical resection followed by EBRT (60 Gy in 30-35 fractions) and adjuvant temozolomide 75 mg/sq.m/day orally on days 1-42, usually 1-1.5h before radiation.
* Postradiation therapy: Temozolomide needs to be continued at higher doses of 150-200 mg/sq.m/day orally on days 1-5 every 28 days.
I hope that would help.
Typically the response time is an hour or two although occasionally it may take longer.
Feel free to write back.
Regards
Dosage guidelines mentioned
Detailed Answer:
Thanks for asking on HealthcareMagic.
I have gone carefully through your query. The following information should be useful for you:
* Adjuvant therapy for Grade II (low-grade infiltrative astrocytomas, oligodendroglioma, mixed gliomas) brain cancer includes temozolomide 150-200 mg/sq.m/day orally on days 1-5 of a 28-day cycle for six to eight cycles.
* Recurrences or progressive, low-grade disease (previously untreated): Temozolomide 75 mg/m 2 orally daily on days 1-21 or 150-200 mg/sq.m orally on days 1-5 of a 28-d cycle until disease progression or for a maximum of 24 cycles.
* For Grade III (anaplastic astrocytoma or oligoastrocytoma): The standard of care is surgical resection followed by External Beam Radiation Therapy (EBRT) (60 Gy in 30-35 fractions) and adjuvant temozolomide, 75 mg/sq.m/day orally on days 1-42, usually 1-1.5 hours before radiation.
* For Post–radiation therapy: Temozolomide needs to be continued at higher doses of 150-200 mg/sq.m/day orally on days 1-5 every 28 day.
* For Grade IV (glioblastoma): The standard of care is surgical resection followed by EBRT (60 Gy in 30-35 fractions) and adjuvant temozolomide 75 mg/sq.m/day orally on days 1-42, usually 1-1.5h before radiation.
* Postradiation therapy: Temozolomide needs to be continued at higher doses of 150-200 mg/sq.m/day orally on days 1-5 every 28 days.
I hope that would help.
Typically the response time is an hour or two although occasionally it may take longer.
Feel free to write back.
Regards
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Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Answered by
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