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Suggest Medicine To Manage Pain After Foot Surgery
Question: Yesterday I had foot surgery I'm trying to find out if the prescription i was given for pain which was traymodol absorbs in your system and turns into codine which makes me very sick. The pharmacist would not give me the prescription. When I called my dr. He said this was not true and he recommended going to a different pharmacy. Is what tbe pharmacist said the truth.
Brief Answer:
Tramadol, no. let me get some sources on that.
Detailed Answer:
"tramadol and its two main metabolites, O-desmethyltramadol (M1) and N-desmethyltramadol (M2) "
--J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Mar 15;864(1-2):109-15. doi: 10.1016/j.jchromb.2008.01.038. Epub 2008 Feb 3. Analysis of tramadol metabolism.
tramadol gets turned into tramadol things (with a "TRAM") and not codeine things (codeine gets turned into morphine and codeine things with a "cod").
The effect of tramadol overlaps slightly with codeine. Codeine works by being made into MORPHINE in the brain. Tramadol works by being ..tramadol and doesn't involve morphine, so that's not it.
No.
The closest I've come is ONE article after looking over hundreds which relates how likely one is to BE SUCCESSFUL AT PAIN might predict how well the other is likely to be successful. But I have to tell you, because how they work is very different this is NOT TRUE IN PRACTICE.
So, the same liver enzymes work on both. The BIG PROBLEM THOUGH is that codeine doesn't work unless THE LIVER CHEWS ON IT making codeine into morphine. But tramadol works directly and this is STOPPED BY THE LIVER CHEWING ON IT and breaking it down into tramadol things mentioned above. so, it's kind of opposite.
Drug Metab Pharmacokinet. 2014;29(1):29-43. Epub 2013 Jun 11.
but, size of the person (there are 100 pound people and 400 pound people), age of people, gender, if they have liver disease from alcohol have a much bigger effect than the genetics.
This is probably what the pharmacist is going by. Large databases just lump drugs together by the pathway of metabolism they share in the liver. Problems with one flag every other drug that is metabolized by the same mechanism. Tramadol and codeine ARE broken down by the same parts of the liver. This really only RARELY has anything to do with why someone had a problme with a particular drug. It has absolutely nothing to do with if they have an allergy to it. It has absolutely nothing to do with if they got too much or too little. It has absolutely nothing to do with if they were given it for a condition where it wouldn't work. It has very little to do with codeine and morphine having direct action on the brain to produce nausea and on blood cells to release histamine and give itching (which tramadol doesn't do any of this).
Doctor right; pharmacist (mostly) wrong.
Tramadol, no. let me get some sources on that.
Detailed Answer:
"tramadol and its two main metabolites, O-desmethyltramadol (M1) and N-desmethyltramadol (M2) "
--J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Mar 15;864(1-2):109-15. doi: 10.1016/j.jchromb.2008.01.038. Epub 2008 Feb 3. Analysis of tramadol metabolism.
tramadol gets turned into tramadol things (with a "TRAM") and not codeine things (codeine gets turned into morphine and codeine things with a "cod").
The effect of tramadol overlaps slightly with codeine. Codeine works by being made into MORPHINE in the brain. Tramadol works by being ..tramadol and doesn't involve morphine, so that's not it.
No.
The closest I've come is ONE article after looking over hundreds which relates how likely one is to BE SUCCESSFUL AT PAIN might predict how well the other is likely to be successful. But I have to tell you, because how they work is very different this is NOT TRUE IN PRACTICE.
So, the same liver enzymes work on both. The BIG PROBLEM THOUGH is that codeine doesn't work unless THE LIVER CHEWS ON IT making codeine into morphine. But tramadol works directly and this is STOPPED BY THE LIVER CHEWING ON IT and breaking it down into tramadol things mentioned above. so, it's kind of opposite.
Drug Metab Pharmacokinet. 2014;29(1):29-43. Epub 2013 Jun 11.
but, size of the person (there are 100 pound people and 400 pound people), age of people, gender, if they have liver disease from alcohol have a much bigger effect than the genetics.
This is probably what the pharmacist is going by. Large databases just lump drugs together by the pathway of metabolism they share in the liver. Problems with one flag every other drug that is metabolized by the same mechanism. Tramadol and codeine ARE broken down by the same parts of the liver. This really only RARELY has anything to do with why someone had a problme with a particular drug. It has absolutely nothing to do with if they have an allergy to it. It has absolutely nothing to do with if they got too much or too little. It has absolutely nothing to do with if they were given it for a condition where it wouldn't work. It has very little to do with codeine and morphine having direct action on the brain to produce nausea and on blood cells to release histamine and give itching (which tramadol doesn't do any of this).
Doctor right; pharmacist (mostly) wrong.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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