Suggest Treatment For Low Grade Depression

Question: I have what i will term "low-grade" depression for most of my adult lfe wherein i could always push through and work and live my life effectively although i always believed there should be more happiness and lightheartedness. i have taken a number of SSRI antidepressants with virtually no effect over the years. I took Wellbutrin Extended Release and some degree of success with that drug but began to suffer memory loss after about 6 years so i got off of it. Now, about 5 years later, i have been prescribed Effexor XR. i started with 37.5 for 1 week, 75 for 4 weeks and 150 for 3 weeks. i have adult ADHD and found that, at 75 mg, i began to experience more organization to my thoughts and began to function better at work and at home. My problem is motivation and focus. Should i expect help from the 225mg dose for these issues? i am convinced that the norepinephrine is what i need. i have also taken Tramadol very occasionally when the pinched nerve in my neck starts acting up. The feeling that i get from the Tramadol is a general sense of good well-being. That's the same thing I remember from Wellbutrin. That is what i am hoping for on the 225mg Effexor XR. Today is day 8 since i upped the dose (with Dr.'s permission of course. Thanks for your thoughts.