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Suggest Treatment For Vitiligo

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Posted on Sat, 26 Apr 2014
Question: Like to know about Vitiligo from a dermatologist. What are the current option of treatment?involving the Neck torso and limbs? Diagnosed about 4 months ago, initially on Topical steroids for about 2 months changed over to Topical Pimecrolimus(for face and neck) &Calcipotriol for limbs and torso, in addition to Phototherapy (had 22 treatment so far) , Antithyroid antibody positive with normal thyroid function. So far some response with repigmentation, also found areas of new areas of depigmentation. How long you have to have Topical treatment, and How long you have to have Phototherapy. When do you decide to stop treatment? Will the darkened surround skin of the lesion due to phototherapy return to normal skin colour once photo therapy stopped ? If so how long it will take to get the normal complexion to to return? Will the skin continue to darken when the phototherapy continues?
doctor
Answered by Dr. Dr. Kakkar (1 hour later)
Brief Answer: Vitiligo treatment Detailed Answer: Hello and Welcome to healthcaremagic I am Dr. Kakkar. I have gone through your concern and understood it. Vitiligo is a condition characterized by the autoimmune destruction of melanocytes, resulting in loss of pigmentation. In vitiligo, there is a partial or total destruction of melanocytes, initially only of the epidermis and later even of the hair follicle, which acts as a reservoir for providing melanocytes during repigmentation. Vitiligo can be of various types depending on the distribution of lesions: 3 types commonly seen are: -Focal Vitiligo -Segmental Vitiligo -Generalised Vitiligo Judging from the distribution of the lesions, you seem to be having a generalised type of vitiligo, where patches are widespread and symmterical involvement is common (e.g Bilateral arms, bilateral legs, trunk and torso etc) Medical therapies are the primary treatment for vitiligo. To enumerate them, they can be divided into topical and oral. --Topicals e.g Topical steroids, Topical immunomodulators like Tacrolimus, Topical PUVA (Melanocyl lotion)etc --Oral e.g Oral PUVA(Melanocyl tablets), NB-UVB phototherapy, Oral steroids etc. For generalised vitiligo, as seems the case here, Phototherapy remains the mainstay of treatment e.g NB-UVB and PUVA. NB-UVB is the most preferred form of therapy for patients with generalised vitiligo since it is safe, effective, well tolerable and gives long lasting results/re-pigmentation. It can also be given in children and even pregnant ladies because of its safety profile. Disadvantages with NB-UVB Phototherapy are: -It requires to be adnministered 3 times in a week for several weeks. -It is expensive. Topical are an adjuvant to systemic treatment and include topical steroids and topical immunomodulators like tacrolimus. They accelerate the response to systemic therapy. At last, I would want to say that Vitiligo is a remitting and relapsing condition and no one can predict the future course of the disease. Treatment is directed at repigmenting the already existing patches with the most appropriate modality suitable for the particular type of vitiligo. Sometimes it responds very well at certain body sites like trunk, limbs and face but remains resistant OR responds slowly at certain body areas like lips(perioral), fingers, palms, soles and scalp etc The duration of phototherapy varies according to the severity/extent of vitiligo. There is no fixed duration for phototherapy. It is individualized for each patient. The duration can vary from a few weeks to a few months depending on the response. Phototherapy can be continued even for maintenance after a satisfactory response. Topical therapy is only for the existing patches of vitiligo and the duration depends on the response. The decision to stop treatment is made usually after satisfactory repigmentation of the patches is achieved OR most of the patches is achieved. For a few resistant patches of vitiligo that remain, Phototherapy can be continued with a topical psoralen Or hand help NB-UVB phototherapy unit, rather than exposing the whole body. Topical therapy is usually continued along with phototherapy. The surrounding dark skin is usually a side effect of phototherapy and fades away gradually in a few weeks, once the treatment is over. This manifest as tanning and is only up to a limit. This is not much of a concern usually with NB-UVB than it is with PUVA Hope this answers your query regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (7 hours later)
Dr Kakkar, Thank you for answering the questions.I found it useful. Do you have to increase the exposure of NB- UVB or can it be kept at a constant level of exposure? Are there any side effects of Pimecrolimus , Calcipotirol to skin and to the other systems of the body? What dictates the time of exposure? Is it safer to have Herbal medication advertised in Indian Media called Lukoskin to supplement the allopathy treatment? At what stage it is adviseable to start this , whether to start now or to wait until stop Allopathy treatment?
doctor
Answered by Dr. Dr. Kakkar (13 hours later)
Brief Answer: Vitiligo treatment Detailed Answer: Hi NB-UVB is increased by 10%-12% in every sitting till the dose which shows faint erythema and perifollicular repigmentation. Thereafter it is kept constant. The time of exposure is dictated by the dose of UVB that is to be given per session Pimecrolimus, calcipotriol are absolutely safe. Some patients can experience mild/transient irritation but it subsides on continued treatment. Herbel medicines are not approved for vitiligo, therefore I wont ask my patients to use them. Lukoskin(defense ministry researched, D.R.D.O) is also actually a psoralen, so it is no different from phototherapy. I think one should stick to the Allopathy because there are so many trials/studies in medical journals and approval for use throughout the world, rather than go for herbal medicines. Its not a good idea to combine allopathy and herbal together because there can be adverse events. regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (36 hours later)
Dear Dr Kakkar, Thank you very much for on your advise and answering my doubts in my mind.This give me more confidence to continue Alopathy treatment. I have another question about Homeopathy as recently I saw a Homeopath practitioner , she suggested to have Arsen Sulf flav 7g pill/ day on a long term basis.I thought this will help to get quicker response.Please advise me whether it is safer to have topical allopathy and oral Homeopath. I also like to know about depigmentation to be prepared for worse case scenario.What is the best and safer method for depigmentation. When the depigmentation done, does it end up like chalkwhite colour or can it be done in any way to get a matching tone of the skin.
doctor
Answered by Dr. Dr. Kakkar (9 hours later)
Brief Answer: Vitiligo treatment Detailed Answer: Hi. Sorry, but I have no idea about homeopathy. For that you need to ask a separate query to a homeopath. In my view, it is not a good idea to combine topical allopathy and oral homeopathy because you will utilizing a part of homepathic treatment and a part of allopathic treatment, therefore it may be that both become ineffective when not utilized to the full potential. I think you should give a fair trial to phototherapy (NB-UVB) Regarding depigmentation, the ingredient which is commonly used is monobenzyl ether of hydroquinone, which cause irreversible and complete destruction of melanocytes. It is available as a topical cream and has to be used twice daily. It will produce a complete depigmentation and therefore a chalk white color/complete depigmentation. It cannot be used to just lighten the color OR match up tone regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (2 hours later)
Dear Dr Kakkar, Many thanks.I will try and stick on to Alopathy. Could you please let me know about the food I eat, anything I have to avoid or any food which is good for this condition. Also noted recently few small areas hyperpigmentation especially near the nose where there was no vitiligo before, I have some concerns about this.Can I be able to apply Sunscreen to these areas when I go for the NB UVB treatment? What else I could do these areas of hyper pigmentation. I thank you so much for all the advise and encouragement. Kind Regards
doctor
Answered by Dr. Dr. Kakkar (11 hours later)
Brief Answer: Vitiligo treatment Detailed Answer: Hi. There are no restrictions to any of the foods nor are there any specific foods that you should take in vitiligo. Yes, you can use a sunscreen at those areas which are not affected by vitiligo. You can also use a moderately potent topical steroid e.g fluticasone propionate cream, twice daily over hyperpigmented spots. regards take care.
Note: Hope the answers resolves your concerns, however for further guidance of skin related queries consult our Dermatologist.Click here to book a consultation

Above answer was peer-reviewed by : Dr. Raju A.T
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Dr. Dr. Kakkar

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Practicing since :2002

Answered : 9612 Questions

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Suggest Treatment For Vitiligo

Brief Answer: Vitiligo treatment Detailed Answer: Hello and Welcome to healthcaremagic I am Dr. Kakkar. I have gone through your concern and understood it. Vitiligo is a condition characterized by the autoimmune destruction of melanocytes, resulting in loss of pigmentation. In vitiligo, there is a partial or total destruction of melanocytes, initially only of the epidermis and later even of the hair follicle, which acts as a reservoir for providing melanocytes during repigmentation. Vitiligo can be of various types depending on the distribution of lesions: 3 types commonly seen are: -Focal Vitiligo -Segmental Vitiligo -Generalised Vitiligo Judging from the distribution of the lesions, you seem to be having a generalised type of vitiligo, where patches are widespread and symmterical involvement is common (e.g Bilateral arms, bilateral legs, trunk and torso etc) Medical therapies are the primary treatment for vitiligo. To enumerate them, they can be divided into topical and oral. --Topicals e.g Topical steroids, Topical immunomodulators like Tacrolimus, Topical PUVA (Melanocyl lotion)etc --Oral e.g Oral PUVA(Melanocyl tablets), NB-UVB phototherapy, Oral steroids etc. For generalised vitiligo, as seems the case here, Phototherapy remains the mainstay of treatment e.g NB-UVB and PUVA. NB-UVB is the most preferred form of therapy for patients with generalised vitiligo since it is safe, effective, well tolerable and gives long lasting results/re-pigmentation. It can also be given in children and even pregnant ladies because of its safety profile. Disadvantages with NB-UVB Phototherapy are: -It requires to be adnministered 3 times in a week for several weeks. -It is expensive. Topical are an adjuvant to systemic treatment and include topical steroids and topical immunomodulators like tacrolimus. They accelerate the response to systemic therapy. At last, I would want to say that Vitiligo is a remitting and relapsing condition and no one can predict the future course of the disease. Treatment is directed at repigmenting the already existing patches with the most appropriate modality suitable for the particular type of vitiligo. Sometimes it responds very well at certain body sites like trunk, limbs and face but remains resistant OR responds slowly at certain body areas like lips(perioral), fingers, palms, soles and scalp etc The duration of phototherapy varies according to the severity/extent of vitiligo. There is no fixed duration for phototherapy. It is individualized for each patient. The duration can vary from a few weeks to a few months depending on the response. Phototherapy can be continued even for maintenance after a satisfactory response. Topical therapy is only for the existing patches of vitiligo and the duration depends on the response. The decision to stop treatment is made usually after satisfactory repigmentation of the patches is achieved OR most of the patches is achieved. For a few resistant patches of vitiligo that remain, Phototherapy can be continued with a topical psoralen Or hand help NB-UVB phototherapy unit, rather than exposing the whole body. Topical therapy is usually continued along with phototherapy. The surrounding dark skin is usually a side effect of phototherapy and fades away gradually in a few weeks, once the treatment is over. This manifest as tanning and is only up to a limit. This is not much of a concern usually with NB-UVB than it is with PUVA Hope this answers your query regards