Brief Answer: It is safe Detailed Answer: Hello Thanks for the query You can take ranitidine in the night, there is no contraindication for it. Ranitidine is a weaker antigastric agent than omeperazole. One good alternative would be to take omeprazole in the morning and at night. I would like to add here that if your symptoms are not getting relieved with omeprazole you could take esomeprazole instead, it is a stronger and a longer acting agent than omeprazole, you would also add on a pro kinetic like a domperidone once in the morning. I hope I was of help, if you have further queries please get back to me I wish you good health Regards

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