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WHAT DRUGS CAN CAUSE DRUG TOXCITY AND DAMAGE LUNGS GIVEN

Posted on Thu, 18 Mar 2021

Question: WHAT DRUGS CAN CAUSE DRUG TOXCITY AND DAMAGE LUNGS GIVEN IN HOSPITAL. DRUGS BEING GIVEN WERE, Hospital Medications: dabigatran etexilate, 150 mg, BID famotidine, 20 mg, BID gabapentin, 300 mg, BID
gabapentin, 600 mg, QHS guaiFENesin 12 hr, 1,200 mg, BID hydrALAZINE, 10 mg, QID
methylPREDNISolone (for Solu-MEDROL) injection, 80 mg, Q8 OLANZapine, 5 mg, QPM propranoloL, 40
mg, DAILY trimethoprim-sulfamethoxazole (160-800 mg / tab), 1 tablet, Once per day on Mon Wed Fri
HYDROmorphone (conc: 0.5 mg/mL)(PF) 15 mg in 30 mL NS albuterol HFA (conc: 90 mcg/puff), 2 puff,
Q4HPRN albuterol-ipratropium (conc: 2.5-0.5 mg/3 mL), 3 mL, Q4HPRN naloxone, 0.1 mg, PRN nicotine
14 mg/24 hr, 1 Patch, DAILY AS NEEDED ondansetron, 4 mg, Q6HPRN sodium chloride 0.65 %, 2 Spray,
Q1HPRN 0.9 % sodium chloride (flush) injection, 3 mL, PRN sodium chloride 0.9% (NS)(FLUSH for
intermittent IV), 30-50 mL, PRN
Scheduled Meds: azithromycin (for ZITHROMAX) 500 mg in NS 250 mL ADDEASE, 500 mg, Q24H
cefTRIAXone (for ROCEPHIN) 1000 mg in NS 50 mL ADDEASE, 1,000 mg, Q24H dabigatran etexilate, 150
mg, BID gabapentin, 300 mg, DAILY gabapentin, 300 mg, QHS morPHINE, 15 mg, Q12 OLANZapine, 5 mg,
QPM propranoloL, 40 mg, DAILY IV Meds: PRN Meds: HYDROcodone-acetaminophen (5-325 mg/tab), 1
tablet, Q4HPRN Or HYDROcodone-acetaminophen (5-325 mg/tab), 2 tablet, Q4HPRN nicotine 14 mg/24
hr, 1 Patch, DAILY AS NEEDED ondansetron, 4 mg, Q6HPRN 0.9 % sodium chloride (flush) injection, 3 mL,
PRN sodium chloride 0.9% (NS)(FLUSH for intermittent IV), 30-50 mL, PRN ALSO FENTANYL 150 mcgs EVERY 30 MIN. AND ATIVAN SEVERAL MGS

Follow up: Dr. Drkaushal85 (0 minute later)

WHAT DRUGS CAN CAUSE DRUG TOXCITY AND DAMAGE LUNGS GIVEN IN HOSPITAL. DRUGS BEING GIVEN WERE, Hospital Medications: dabigatran etexilate, 150 mg, BID famotidine, 20 mg, BID gabapentin, 300 mg, BID
gabapentin, 600 mg, QHS guaiFENesin 12 hr, 1,200 mg, BID hydrALAZINE, 10 mg, QID
methylPREDNISolone (for Solu-MEDROL) injection, 80 mg, Q8 OLANZapine, 5 mg, QPM propranoloL, 40
mg, DAILY trimethoprim-sulfamethoxazole (160-800 mg / tab), 1 tablet, Once per day on Mon Wed Fri
HYDROmorphone (conc: 0.5 mg/mL)(PF) 15 mg in 30 mL NS albuterol HFA (conc: 90 mcg/puff), 2 puff,
Q4HPRN albuterol-ipratropium (conc: 2.5-0.5 mg/3 mL), 3 mL, Q4HPRN naloxone, 0.1 mg, PRN nicotine
14 mg/24 hr, 1 Patch, DAILY AS NEEDED ondansetron, 4 mg, Q6HPRN sodium chloride 0.65 %, 2 Spray,
Q1HPRN 0.9 % sodium chloride (flush) injection, 3 mL, PRN sodium chloride 0.9% (NS)(FLUSH for
intermittent IV), 30-50 mL, PRN
Scheduled Meds: azithromycin (for ZITHROMAX) 500 mg in NS 250 mL ADDEASE, 500 mg, Q24H
cefTRIAXone (for ROCEPHIN) 1000 mg in NS 50 mL ADDEASE, 1,000 mg, Q24H dabigatran etexilate, 150
mg, BID gabapentin, 300 mg, DAILY gabapentin, 300 mg, QHS morPHINE, 15 mg, Q12 OLANZapine, 5 mg,
QPM propranoloL, 40 mg, DAILY IV Meds: PRN Meds: HYDROcodone-acetaminophen (5-325 mg/tab), 1
tablet, Q4HPRN Or HYDROcodone-acetaminophen (5-325 mg/tab), 2 tablet, Q4HPRN nicotine 14 mg/24
hr, 1 Patch, DAILY AS NEEDED ondansetron, 4 mg, Q6HPRN 0.9 % sodium chloride (flush) injection, 3 mL,
PRN sodium chloride 0.9% (NS)(FLUSH for intermittent IV), 30-50 mL, PRN ALSO FENTANYL 150 mcgs EVERY 30 MIN. AND ATIVAN SEVERAL MGS

Answered by Dr. Drkaushal85 (56 minutes later)

Brief Answer:
None of them cause lung damage.

Detailed Answer:
Thanks for your question on Ask a doctor forum.
I can understand your concern.
I have gone through the drug list you have mentioned.
Honestly speaking, all these are commonly used drugs and none of them is believe to cause lung damage. But yes, some of the drugs can damage lungs if given for longer duration like 2-3 months.
May I know
1. Any CT scan report is done?
2. Any Pulmonary Function Test?
3. May I know your main symptoms?
4. Total days of medications?
Please reply me answers of above asked questions so that I can guide you better about medicines and investigations.
Wish you good health. Thanks.

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Answered by Dr. Drkaushal85 (0 minute later)

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Drkaushal85 (3 days later)

THIS IS FOR MY WIFE WHO DIED 6/14. SHE WAS ON HYDROCODONE, GABAPENTAN, OLANZAPINE, MORPHINE FOR LONG TIME ,THEY STARTED HER ,ON OTHER DRUGS DURING TWOM WEEEK STAY AT HOSPITAL. OVER DOSED ON DILAUDID AND FENTANYL SEVERAL TIMES.

Follow up: Dr. Drkaushal85 (0 minute later)

Answered by Dr. Drkaushal85 (18 hours later)

Brief Answer:
Any reports you have?

Detailed Answer:
Thanks for your follow up question on Ask a doctor forum.
I can understand your concern.
First of all sorry for late reply as I was busy.
I want to know
1. Any reports you have like CT thorax and PFT (Pulmonary Function Test)?
2. Any drug levels done?
Please reply me answers of above asked questions so that I can guide you better. Wish you good health. Thanks.

Above answer was peer-reviewed by : Dr. Yogesh D

Answered by Dr. Drkaushal85 (0 minute later)

Above answer was peer-reviewed by : Dr. Yogesh D

Follow up: Dr. Drkaushal85 (27 hours later)

I DO NOT SEE ANY RESULTS FROM CT SCAN. NO PULMONARY TEST AND NO DRUG LEVEL TEST I SEE. EVEN THE AUTOPSY HAD NO TESTS DONE. THEY CONTINUED THROUGH THE WHOLE TWO WEEKS GUESSING WHAT WAS CAUSING THE O2 THEY WERE GIVING HER TO KEEP GOING UP TO HOLD HER BLOOD O2 TO STAY ABOVE 90%

Follow up: Dr. Drkaushal85 (0 minute later)

Answered by Dr. Drkaushal85 (24 hours later)

Brief Answer:
But without CT thorax and PFT, no one can diagnose drug damage.

Detailed Answer:
Thanks for your follow up question on Ask a doctor forum.
I can understand your concern.
Honestly speaking, without CT thorax and PFT, no one can diagnose drug induced lung damage.
Any chest x ray you have?
And in autopsy, lung damage will definitely be there if it is drug related lung damage.

Above answer was peer-reviewed by : Dr. Prasad