
What Are The Symptoms Of Metastic Colon Cancer?

Question: How effective is avastin if added with chemotherpay than chemo
Alone in metastic colon cancer ?
Is it worth taking ?
Male
Aged 66.
Alone in metastic colon cancer ?
Is it worth taking ?
Male
Aged 66.
Brief Answer:
yes it prolongs survival
Detailed Answer:
Hi
Thanks for your query.
Avastin on an average adds six months of life to that obtained by chemo alone (say 2.5 year vs 2 yr). But this is for the general population. Some patients do well than others and can survive 3-4 years. But for that avastin needs to be continued as long as disease is under control. If you take it only for six months and then stop, benefit may not be as much.
Hope this helps. I will be available for followup.
Regards
yes it prolongs survival
Detailed Answer:
Hi
Thanks for your query.
Avastin on an average adds six months of life to that obtained by chemo alone (say 2.5 year vs 2 yr). But this is for the general population. Some patients do well than others and can survive 3-4 years. But for that avastin needs to be continued as long as disease is under control. If you take it only for six months and then stop, benefit may not be as much.
Hope this helps. I will be available for followup.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


We are stuck
As my dad was initially stage 3 and now stage 4. Please see letter attached .
Prob came as first chemo irinotecan failed when there first was a liver met discovered in AUgust 2014.
After bowel surgery he was on adjuvant xeloda but that failed too as he developed a liver met .
Does this mean no chemo
Will work ?is the cancer chemo resistant ?
As my dad was initially stage 3 and now stage 4. Please see letter attached .
Prob came as first chemo irinotecan failed when there first was a liver met discovered in AUgust 2014.
After bowel surgery he was on adjuvant xeloda but that failed too as he developed a liver met .
Does this mean no chemo
Will work ?is the cancer chemo resistant ?
Brief Answer:
There are options
Detailed Answer:
If he has never received oxaliplatin, I would recommend capecitabine (xeloda) +oxaliplatin +bev if feasible. If KRAS mutation absent then cetuximab/panitumumab another option along with chemo.
If failed oxali and irinotecan bioth then regorafenib may be considered.
There are options
Detailed Answer:
If he has never received oxaliplatin, I would recommend capecitabine (xeloda) +oxaliplatin +bev if feasible. If KRAS mutation absent then cetuximab/panitumumab another option along with chemo.
If failed oxali and irinotecan bioth then regorafenib may be considered.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


He's just started oxyplatin and ralitetrexed he's had 1 session so far. Not 5 fu and initially had muscle spasm in chest with it
We are pushing to Add avastin .is this a good combination ?
Can this also fail ?
We are pushing to Add avastin .is this a good combination ?
Can this also fail ?
Brief Answer:
yes this will be a good combination
Detailed Answer:
Any combination in metastatic cancer is trial and error and can fail. But there is chance of working also.
yes this will be a good combination
Detailed Answer:
Any combination in metastatic cancer is trial and error and can fail. But there is chance of working also.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


What percent chance would u say there is of this combo worlkjng ?
Can avastin be added to this combination ?
Can avastin be added to this combination ?
Brief Answer:
Good response around 20%
Detailed Answer:
Another 20-30% stable disease for certain period. If you add avastin, then response rate may increase by another 10-20%
Good response around 20%
Detailed Answer:
Another 20-30% stable disease for certain period. If you add avastin, then response rate may increase by another 10-20%
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


But can
Avastin b given with 5fu or xeloda only . Can it be combined with ralititrexed ?
Also if he had history of minor attack and blood clots in 2013 is avastin safe still?
U think it's worth it in this situation ?
Avastin b given with 5fu or xeloda only . Can it be combined with ralititrexed ?
Also if he had history of minor attack and blood clots in 2013 is avastin safe still?
U think it's worth it in this situation ?
Brief Answer:
yes it can be
Detailed Answer:
It can be combined with 5FU or xeloda as well as raltitrexed alone. There are small studies for the same.
Minor clot in 2013 should not be a problem.
I think it should be given a try
yes it can be
Detailed Answer:
It can be combined with 5FU or xeloda as well as raltitrexed alone. There are small studies for the same.
Minor clot in 2013 should not be a problem.
I think it should be given a try
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


Brief Answer:
yes he can
Detailed Answer:
8-9 is a lot in the sense that surgery is not feasible but chemo should work an all of them if it does, at all.
yes he can
Detailed Answer:
8-9 is a lot in the sense that surgery is not feasible but chemo should work an all of them if it does, at all.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


Ok so would chemo shrink the mets ?
Do we have any option if chemo fails ?
He's KRAS mutant , are here ppl with this where no chemo
Works ?
Do we have any option if chemo fails ?
He's KRAS mutant , are here ppl with this where no chemo
Works ?
Brief Answer:
yes chemo can shrink the mets
Detailed Answer:
In kras mutant patient avastin can work.
If chemo and avastin does not work we can try regorafenib. If that too fails then palliative care.
Unfortunately there are many patients where nothing works.
yes chemo can shrink the mets
Detailed Answer:
In kras mutant patient avastin can work.
If chemo and avastin does not work we can try regorafenib. If that too fails then palliative care.
Unfortunately there are many patients where nothing works.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


Ok . Does the cea depend on how many mets he has ?
His is 65. Do some ppl have high than this ? Is this high for metastic colon cancer ?
His is 65. Do some ppl have high than this ? Is this high for metastic colon cancer ?
Brief Answer:
yes it can be higher
Detailed Answer:
CEA levels vary widely. I have seen in thousands also.
But in one patient its values over time suggest disease response to chemo ( if it goes down) or disease growth ( if increasing)
yes it can be higher
Detailed Answer:
CEA levels vary widely. I have seen in thousands also.
But in one patient its values over time suggest disease response to chemo ( if it goes down) or disease growth ( if increasing)
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


What diffetence is there from a cea of 65 and a cea of say 500?
Brief Answer:
in two separate patients it does not matter
Detailed Answer:
But if in one patient it increases from 65 to 500 then definitely chemo is not working
in two separate patients it does not matter
Detailed Answer:
But if in one patient it increases from 65 to 500 then definitely chemo is not working
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar


Ok my dad's was 12 in dec and by march end was 65
Brief Answer:
that signifies disease progression
Detailed Answer:
This much rise suggests disease progression
that signifies disease progression
Detailed Answer:
This much rise suggests disease progression
Note: For further queries related to kidney problems Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar

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