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What Causes Diabetes Insipidus?

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Posted on Wed, 29 Apr 2015
Question: My head feels full of pressure but I do not have a cold. My vision is blurry. I have lost 33 lbs in the last month. I have no energy. My blood sugar is way off but the dr's say my blood sugar is fine. I have been having back pain. I urinate often and am always thirsty. I have stomach pain near the gall bladder and the appendix. The ct scans all came back fine. I feel like I am going crazy. I am 44 years old and I am getting no answers.
doctor
Answered by Dr. Mohammed Taher Ali (4 hours later)
Brief Answer:
Suspicious of Diabetes insipidus

Detailed Answer:
Dear Sir,
Thanks for posting your query on HCM.
I appreciate your concern for increased urination and thirst.
I have gone through your problems diligently, I am of the opinion that symptoms are suggestive of diabetes insipidus.

This disorder is associated with a hormone (ADH) produced by pituitary gland (a small gland in the brain).
ADH acts on the kidneys to increase the reabsorption of water and hence responsible for concentration of the urine.

There are two types of this disorder:

Central diabetes insipidus in which too little ADH is produced or may be not produced at all.
Nephrogenic diabetes insipidus in which there is enough ADH produced, but the kidneys can't respond to it.

As as result of either of the two above conditions, the kidneys can't do their job of conserving water hence causing increased urination and thirst with dehydration.

I would advice you to kindly consult an endocrinologist for further evaluation and relevant lab investigations like Urine analysis, Water deprivation test and MRI to confirm the diagnosis and appropriate treatment.

It is hoped the the suggestions given above could be useful in detecting the cause and eventually an effective treatment.
Regards
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Mohammed Taher Ali (9 hours later)
I forgot to mention that I also have bubbles or foam every time I urinate and my back pain is beneath my shoulder blade and just to the right of my spine. If my problem is from too little or too much ADH, what is the treatment for this problem?
doctor
Answered by Dr. Mohammed Taher Ali (1 hour later)
Brief Answer:
Treatment depends upon the type of diabetes insipidus.

Detailed Answer:
Welcome back to HCM.

I appreciate your concern for the possible treatment modalities.
I depends upon the type of Diabetes insipidus.

After the confirmation that it is due to deficiency of ADH (Central diabetes insipidus) the treatment consists of taking Desmopressin hormone (which acts as a substitute or replacement for ADH).

If the diseases is due to normal or high level of ADH but lack of its response from the kidneys ( Nephrogenic diabetes insipidus) then treatment consists of taking Demeclocyline tablets.

I would advice you to first confirm the diagnosis by the relevant investigations as advised earlier.
Hope this answers your query.
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
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Answered by
Dr.
Dr. Mohammed Taher Ali

General & Family Physician

Practicing since :1988

Answered : 6261 Questions

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What Causes Diabetes Insipidus?

Brief Answer: Suspicious of Diabetes insipidus Detailed Answer: Dear Sir, Thanks for posting your query on HCM. I appreciate your concern for increased urination and thirst. I have gone through your problems diligently, I am of the opinion that symptoms are suggestive of diabetes insipidus. This disorder is associated with a hormone (ADH) produced by pituitary gland (a small gland in the brain). ADH acts on the kidneys to increase the reabsorption of water and hence responsible for concentration of the urine. There are two types of this disorder: Central diabetes insipidus in which too little ADH is produced or may be not produced at all. Nephrogenic diabetes insipidus in which there is enough ADH produced, but the kidneys can't respond to it. As as result of either of the two above conditions, the kidneys can't do their job of conserving water hence causing increased urination and thirst with dehydration. I would advice you to kindly consult an endocrinologist for further evaluation and relevant lab investigations like Urine analysis, Water deprivation test and MRI to confirm the diagnosis and appropriate treatment. It is hoped the the suggestions given above could be useful in detecting the cause and eventually an effective treatment. Regards