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What Causes Dizziness And Headaches When Suffering From Enlarged Spleen?
Question: I've been undergoing very extensive testing since a CT showed that I have a moderately enlarged spleen. I've had a liver biopsy that showed normal liver function. I've had a bone marrow biopsy, in which the doctor was unable to obtain tissue, but the aspirate sample indicated possible MDS or MPN. I've been consistently iron deficient, while my hematocrit and hemaglobin levels remain in range. I've had an iron infusion that has dramatically increased my energy level (which was much needed). I've had a CT PET which only showed abnormal FDG SUV in my T6 vertebral body. My blood tests have consistenly shown high RDW, MPV, and now high B12. My RPI is very low. I've had more blood tests ordered, as well as an MRI to evaluate the T6 activity. As far as my physical symtoms, I have pain in the area of my spleen and lower ribs, although my spleen hasn't become any larger in the last five months. I feel dizzy and disoriented often, headaches, and fatigue.
Any ideas what may be causing these findings and symptoms?
Any ideas what may be causing these findings and symptoms?
Brief Answer:
SLight Iron deficiency anemia. needs correlation
Detailed Answer:
Thank you for asking
before going in to your la works and hematological variations , let me tell you different scenarios where spleen may be enlarged and needs further clinical correlation.
A number of infections and diseases can contribute to an enlarged spleen. The effects on your spleen may be only temporary, depending on how well your treatment works. Contributing factors include:
Viral infections, such as mononucleosis
Bacterial infections, such as syphilis or an infection of your heart's inner lining (endocarditis)
Parasitic infections, such as malaria
Cirrhosis and other diseases affecting the liver
Various types of hemolytic anemia — a condition characterized by premature destruction of red blood cells
Blood cancers, such as leukemia, and lymphomas, such as Hodgkin's disease
Metabolic disorders, such as Gaucher's disease and Niemann-Pick disease
Pressure on the veins in the spleen or liver or a blood clot in these veins
I suggest MDS and MPN is quite overrated as slight iron deficieny anemia should not be and can not be correlated with a morbid and complicated issue like MDS.
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. In your case it is remotely impossible to be MDS or MPN.
B12 higher levels are blessings and never heard of to be the problem. OS no worries for that.
Age related bone marrow changes and vertebral wear and tear may vary the Standard Uptake value of Fluorescent deoxyglucose in vertebrates , so unless there is any prominent suspicion of any metabolic or hematologic or malignancy , these values are of least significance.
Elevated RDW is just because fo iron deficinecy and you yourself mentioned you felt energetic with iron supplements infusions unlike MDS and MPN where iron is a poison as iron is already overloaded due to sideroblastosis.
Nut shell, to me it is no more than a variable iron deficiency anemia and needs to be correlated clinically further by an expert hematologist and a competent diagnostician as this forum is beyond the scope of that, still i tried my best to sooth your nerves and reassure you of it to be be most likely a mere iron deficiency anemia easily manageable with Supplements and correlation.
I hope it helps. take good care of yourself and dont forget to close the discussion please.
may the odds be ever in your favour.
Regards
Khan
SLight Iron deficiency anemia. needs correlation
Detailed Answer:
Thank you for asking
before going in to your la works and hematological variations , let me tell you different scenarios where spleen may be enlarged and needs further clinical correlation.
A number of infections and diseases can contribute to an enlarged spleen. The effects on your spleen may be only temporary, depending on how well your treatment works. Contributing factors include:
Viral infections, such as mononucleosis
Bacterial infections, such as syphilis or an infection of your heart's inner lining (endocarditis)
Parasitic infections, such as malaria
Cirrhosis and other diseases affecting the liver
Various types of hemolytic anemia — a condition characterized by premature destruction of red blood cells
Blood cancers, such as leukemia, and lymphomas, such as Hodgkin's disease
Metabolic disorders, such as Gaucher's disease and Niemann-Pick disease
Pressure on the veins in the spleen or liver or a blood clot in these veins
I suggest MDS and MPN is quite overrated as slight iron deficieny anemia should not be and can not be correlated with a morbid and complicated issue like MDS.
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. In your case it is remotely impossible to be MDS or MPN.
B12 higher levels are blessings and never heard of to be the problem. OS no worries for that.
Age related bone marrow changes and vertebral wear and tear may vary the Standard Uptake value of Fluorescent deoxyglucose in vertebrates , so unless there is any prominent suspicion of any metabolic or hematologic or malignancy , these values are of least significance.
Elevated RDW is just because fo iron deficinecy and you yourself mentioned you felt energetic with iron supplements infusions unlike MDS and MPN where iron is a poison as iron is already overloaded due to sideroblastosis.
Nut shell, to me it is no more than a variable iron deficiency anemia and needs to be correlated clinically further by an expert hematologist and a competent diagnostician as this forum is beyond the scope of that, still i tried my best to sooth your nerves and reassure you of it to be be most likely a mere iron deficiency anemia easily manageable with Supplements and correlation.
I hope it helps. take good care of yourself and dont forget to close the discussion please.
may the odds be ever in your favour.
Regards
Khan
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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