
What Causes Elevated Bilurubin And AST Numbers?

Yes Humira can cause liver enzymes to raise
Detailed Answer:
Hi,
Thanks for posting your query.
I am Dr.R.K and I am pleased to assist you.
Yes, Humira can affect the liver and cause the liver enzymes to raise.
But there are many different causes for liver enzymes raise. Having Crohn's disease, you are prone for the following liver related disorders.
Crohn's diease can cause
1. Asymtomatic elevation of liver enzymes
2. Can be associated with Primary scleroing cholangitis ( which can increase the liver enzymes)
3. Can be associated with fatty liver
4, Can be associated with auotimmune hepatitis ( which can increase the liver enzymes)
I hope that answers your question.
Let me know if I can assist you further.
Regards,
Dr.R.K.


I was diagnosed with fatty liver last year but primary sclerosing colangitis was ruled out. I also do not have autoimmune hepatitis. Would removing myself from Humira positively impact my liver numbers, or would concerns over the potential end of my remission from Crohns disease outweigh the potential damage to my liver that is occurring at the present time?
What is the AST number now?
Detailed Answer:
What is the AST number now?


Fasting Status 15.0 Range
Sodium 138 135 - 145 mmol/L
Potassium 4.0 3.4 - 5.1 mmol/L
Chloride 104 98 - 107 mmol/L
Co2 25 21 - 32 mmol/L
Anion Gap 13 10 - 20 mmol/L
Glucose 93 65 - 99 mg/dL
Bun 13 10 - 20 mg/dL
Creatinine 1.03 0.50 - 1.30 mg/dL
Gfr XXXXXXX XXXXXXX >60 >59 - >59 Units = mL/min/1.73m2
Gfr, Estimate >60 >59 - >59 Units = mL/min/1.73m2
Bun/creatinine Ratio 13 7 - 25
Calcium 8.8 8.4 - 10.2 mg/dL
Total Bilirubin 3.4 0.2 - 1.0 mg/dL H
Ast/sgot 50 <38 Units/L - <38 Units/L H
Alt/sgpt 104 <79 Units/L - <79 Units/L H
Alk Phosphatase 144 45 - 117 Units/L H
Total Protein 7.3 6.4 - 8.2 g/dL
Albumin 4.0 3.4 - 5.0 g/dL
Globulin 3.3 2.0 - 4.0 g/dL
A/g Ratio, Serum 1.2 1.0 - 2.4
I had just injected myself with Humira the day before as a side note
AST,ALT increased
Detailed Answer:
Hi,
Your AST and ALT are raised.
As said earlier both Crohn's disease and Humira can alter liver function.
If the symptoms of Crohn's disease are under control you can discuss with your doctor about stopping Humira.
Regards,
Dr.R.K.

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