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What Causes Low Testosterone Levels Post Prostate Cancer Treatment With Goserelin?
Question: My prostate cancer was treated with Goserelin. My testosterone fell to the castration level. This produced side effects. My testosterone recovered but I still live with some side effects.
Are all the 127 published side effects resulting only from low testosterone. If so why do I still have them? Alternately, can goserelin attack other glands or other functions such as neurological and cause long term or permanent changes?
XXXXXXX XXXXX
Are all the 127 published side effects resulting only from low testosterone. If so why do I still have them? Alternately, can goserelin attack other glands or other functions such as neurological and cause long term or permanent changes?
XXXXXXX XXXXX
Brief Answer:
probably it doesn't have any direct effect
Detailed Answer:
Hi
Thanks for your query.
You do have a point. We also notice this in clinical practice. However, so far research has failed to show any direct toxicity of goserelin which is not mediated via the androgen pathway.
Hence a probable explanation is that the effects of androgen deprivation are longstanding even if the testosterone comes back. For example, the bone loss arising from androgen deprivation lasts for many years even after the testosterone recovers.
Hope this helps. I will be available to answer further follow up queries, if any.
Regards
probably it doesn't have any direct effect
Detailed Answer:
Hi
Thanks for your query.
You do have a point. We also notice this in clinical practice. However, so far research has failed to show any direct toxicity of goserelin which is not mediated via the androgen pathway.
Hence a probable explanation is that the effects of androgen deprivation are longstanding even if the testosterone comes back. For example, the bone loss arising from androgen deprivation lasts for many years even after the testosterone recovers.
Hope this helps. I will be available to answer further follow up queries, if any.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Dr. XXXXXXX
This exactly explains my situation. Unfortunately, my health support team does not agree. Four years of suffering, no diagnosis, no treatment, no medication.
I would like to access any published material, clinical studies, other opinions, that will help support my argument. I have searched the internet but no one seems to have dealt with this subject.
What do you suggest, how should I/we proceed?
XXXXXXX XXXXX
This exactly explains my situation. Unfortunately, my health support team does not agree. Four years of suffering, no diagnosis, no treatment, no medication.
I would like to access any published material, clinical studies, other opinions, that will help support my argument. I have searched the internet but no one seems to have dealt with this subject.
What do you suggest, how should I/we proceed?
XXXXXXX XXXXX
Brief Answer:
yes, sure there are
Detailed Answer:
Thanks for follow-up.
This is well known that cancer therapy has various late-effects some of which are quite persistent.
Please go through this link, it is a preview from a book published from MD XXXXXXX cancer center, XXXXXXX XXXXXXX Probably page 105 describes your situation.
https://books.google.co.in/books?id=YIjLBAAAQBAJ&pg=PA103&lpg=PA103&dq=late+effects+of+androgen+deprivation&source=bl&ots=BTxYLhen6t&sig=sarPIfZXTGQ_zZZZ5zYJQTHFFrs&hl=en&sa=X&ei=23wXVcj0BoKfugS-koH4DQ&ved=0CF0Q6AEwCQ#v=onepage&q=late%20effects%20of%20androgen%20deprivation&f=false
I am sure we can do something to improve your symptoms.
yes, sure there are
Detailed Answer:
Thanks for follow-up.
This is well known that cancer therapy has various late-effects some of which are quite persistent.
Please go through this link, it is a preview from a book published from MD XXXXXXX cancer center, XXXXXXX XXXXXXX Probably page 105 describes your situation.
https://books.google.co.in/books?id=YIjLBAAAQBAJ&pg=PA103&lpg=PA103&dq=late+effects+of+androgen+deprivation&source=bl&ots=BTxYLhen6t&sig=sarPIfZXTGQ_zZZZ5zYJQTHFFrs&hl=en&sa=X&ei=23wXVcj0BoKfugS-koH4DQ&ved=0CF0Q6AEwCQ#v=onepage&q=late%20effects%20of%20androgen%20deprivation&f=false
I am sure we can do something to improve your symptoms.
Note: For further queries related to kidney problems Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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