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What Causes Memory Loss And Topographical Disorientation After Taking Scopolamine?

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Posted on Tue, 16 Jun 2015
Question: Three years ago my wife was prescribed a scopolamine patch that she used for three weeks during a trip to Australia that was needed to address her history of motion sickness. She did not have motion sickness during the trip but suffered from memory loss and loss of sense of direction. The problem has persisted. There was a diagnosis of mild cognitive impairment and Adderall was prescribed. There was no significant improvement in memory or sense of direction. Recently she was prescribed Namenda which seemed to worsen the problem and cause mood changes. She has had a history of problems with pain medications and is very cautious about using them. Is it possible that there has been a misdiagnosis of Alzheimer's or dementia and that she is really suffering from the continuing impact of scopolamine and the usage of Adderall and Namenda?
doctor
Answered by Dr. Shubham Mehta (1 hour later)
Brief Answer:
scopolamine induced or age related cognitive impairment.

Detailed Answer:
Hello
Welcome to HCM.
I understand your concerns for your wife.

Scopolamine is well-known in inducing cognitive deficits but most of the effects are short-term.

There is a possibility that she might have developed memory loss and loss of sense of direction due to scopolamine. Or it could have acted as a contributing factor for an ongoing age-related cognitive impairment in her.

I am unable to understand why adderall was given to her for mild cognitive impairment. This is not the first line drug.

Irrespective of why there were cognitive deficits, I would suggest donepezil (aricept) for her for mild cognitive impairment. She is not tolerating namenda. So, Aricept would be the best choice for her.
Kindly consult her doctor and discuss this.

Hope this helps.
Take care.
Thanks.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shubham Mehta (2 hours later)
Thank you. My point is this: prior to scopolamine my wife had no memory problems and her sense of direction was equal to a GPS. Since that time her memory and sense of direction have declined. Doctors have prescribed Adderall, Aircept, and Namenda with no improvements and some decline. Long before the scopolamine she had a strong sensitivity to pain medications and on occasion had asked doctors to prescribe weaker solutions. When they insisted on the stronger solution she experienced hallucinations and they then settled on a lesser alternative. My view is that the source of her problem and damage is scopolamine and the solutions to address Alzheimer's and dementia are not the answer. Is there any basis for my conclusion and is there any way to determine what is the problem and what should be the solution. Thank you.
Thank you. My point is this: prior to scopolamine my wife had no memory problems and her sense of direction was equal to a GPS. Since that time her memory and sense of direction have declined. Doctors have prescribed Adderall, Aircept, and Namenda with no improvements and some decline. Long before the scopolamine she had a strong sensitivity to pain medications and on occasion had asked doctors to prescribe weaker solutions. When they insisted on the stronger solution she experienced hallucinations and they then settled on a lesser alternative. My view is that the source of her problem and damage is scopolamine and the solutions to address Alzheimer's and dementia are not the answer. Is there any basis for my conclusion and is there any way to determine what is the problem and what should be the solution. Thank you.

Asked by Me , 0 minutes ago
Thank you. My point is this: prior to scopolamine my wife had no memory problems and her sense of direction was equal to a GPS. Since that time her memory and sense of direction have declined. Doctors have prescribed Adderall, Aircept, and Namenda with no improvements and some decline. Long before the scopolamine she had a strong sensitivity to pain medications and on occasion had asked doctors to prescribe weaker solutions. When they insisted on the stronger solution she experienced hallucinations and they then settled on a lesser alternative. My view is that the source of her problem and damage is scopolamine and the solutions to address Alzheimer's and dementia are not the answer. Is there any basis for my conclusion and is there any way to determine what is the problem and what should be the solution. Thank you.
doctor
Answered by Dr. Shubham Mehta (3 hours later)
Brief Answer:
a neurological examination needed.

Detailed Answer:
You are most welcome :)

Scopolamine-induced cognitive deficits are almost similar to Alzheimer's dementia.
Even, scopolamine has been used in research to artificially induce dementia and then study novel drug treatments for the same.
Therefore, the drug treatment for both conditions are similar.

However, I am concerned about how could the memory deficits persist for 3 long years if they were scopolamine-induced. This is a bit unusual. Usually these deficits are short-lasting and reversible.

Thus, I would suggest you to consult a neurologist for proper examination of your wife. It has to examined whether there are just isolated memory deficits or an ongoing neurological pathology.
If needed, a brain imaging (MRI or CT scan) should be conducted for her.
This will guide in further treatment.

Hope I have answered your query satisfactorily.

Feel free to ask further.
I wish speedy recovery for your wife.
Thanks.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shubham Mehta

Psychiatrist

Practicing since :2008

Answered : 2144 Questions

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What Causes Memory Loss And Topographical Disorientation After Taking Scopolamine?

Brief Answer: scopolamine induced or age related cognitive impairment. Detailed Answer: Hello Welcome to HCM. I understand your concerns for your wife. Scopolamine is well-known in inducing cognitive deficits but most of the effects are short-term. There is a possibility that she might have developed memory loss and loss of sense of direction due to scopolamine. Or it could have acted as a contributing factor for an ongoing age-related cognitive impairment in her. I am unable to understand why adderall was given to her for mild cognitive impairment. This is not the first line drug. Irrespective of why there were cognitive deficits, I would suggest donepezil (aricept) for her for mild cognitive impairment. She is not tolerating namenda. So, Aricept would be the best choice for her. Kindly consult her doctor and discuss this. Hope this helps. Take care. Thanks.