What Causes Of Low Cd4/Cd8 Ratio?

Posted on Wed, 2 Mar 2022

Question: Hi doctor

Could you please advise about what would be the cause of low Cd4/Cd8 ratio

Results were ( .9 )
While normal is (2)

Please mind that I am

HIV type 1 & 2 - NEGATIVE
Hepatitis a b c - NEGATIVE

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CBC results are attached :

Answered by Dr. Drkaushal85 (1 hour later)

Brief Answer:
This reflects T cell abnormal functions.

Detailed Answer:

Hi,

Other than HIV infection, low CD4/CD8 ratio is seen with Thymoma (tumour of thymus gland) and some of the autoimmune diseases.
CD4 and CD8 cells are actually T cells produced by thymus gland.
So any abnormality in thymus gland causes fluctuations in CD4 and CD8 levels.
Slight abnormality in ratio is not worrisome.
So please let me know
1. What are your exact CD4 and CD8 values?
2. Have you ever screened for connective tissue diseases?
3. What are your symptoms?
Please reply me answers of above asked questions, so that I can guide you better.

I will be happy to help you further. Wish you good health. Thanks.

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Drkaushal85 (56 minutes later)

Just uploaded the cd4/cd8 result

I measured by dividing the result of CD4 by the result of CD8

CD4- 35.8%
Over
CD8- 39.8%

Which equals = .9

While normal results should equal = 2

Symptoms are:

Migraines, fatigue , IBS and anxiety

Answered by Dr. Drkaushal85 (5 hours later)

Brief Answer:
Get done connective tissue screening.

Detailed Answer:

Hi,

Your symptoms are more suggestive of stress and anxiety.
I don't think they are due to low CD4 /CD8 ratio.
So no need to worry much for this low ratio.
Get done connective tissue screening, ANA (anti nuclear antibody) titer.
If this titer is normal then no need to worry much.
Have you ever undergone ANA level?

I will be happy to help you further. Wish you good health. Thanks.

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Drkaushal85 (7 hours later)

ANA- negative
CBC - normal
ESR- normal
CRP- normal
Urinalysis- normal
S. creatinine- normal
RF - did not test

Answered by Dr. Drkaushal85 (3 hours later)

Brief Answer:
No need to worry much for low CT4 /CD8 ratio.

Detailed Answer:

Hi,

No need to worry much as all your reports are normal.
No need to worry for low CT4 /CD8 ratio.
Your symptoms are mostly due to stress and anxiety.
Please let me know
1. Are you consulting psychiatrist?
2. Are you taking any medicines at present?
Please reply me answers of above asked questions, so that I can guide you better.

I will be happy to help you further. Wish you good health. Thanks.

Above answer was peer-reviewed by : Dr. Yogesh D

Follow up: Dr. Drkaushal85 (30 minutes later)

Yes, I sometimes go to psychotherapy and I have been on

Sertraline and Xanax for 10 years

Answered by Dr. Drkaushal85 (20 minutes later)

Brief Answer:
You need propranolol and flunarizine combination.

Detailed Answer:

Hi,

You are on treatment.
In my opinion, you should definitely consult psychiatrist again and start treatment for migraine.
You will mostly improve with propranolol and flunarizine combination.
Please let me know
1. Before how many days you have consulted psychiatrist?
2. What is the stressor in your life?
3. Why you undergo CD4 and CD8 counts? I mean were you symptomatic at that time?
Please reply me answers of above asked questions, so that I can guide you better.

I will be happy to help you further. Wish you good health. Thanks.

Above answer was peer-reviewed by : Dr. Yogesh D

Follow up: Dr. Drkaushal85 (1 hour later)

1. Before how many days you have consulted psychiatrist?

Years

2. What is the stressor in your life?

Work (managing staff)

3. Why you undergo CD4 and CD8 counts? I mean were you symptomatic at that time?

Complained of being very much prone to cold or flu like symptoms

Answered by Dr. Drkaushal85 (2 hours later)

Brief Answer:
You should definitely consult psychiatrist now.

Detailed Answer:

Hi,

In my opinion, you should definitely consult the Psychiatrist at this outset.
Try to reduce stress at the workplace.

Start prophylactic migraine treatment in the form of Propranolol and flunarizine combination at night time.
This will definitely help you.

No need to worry about low CD4 /CD8 ratio.
And your recurrent cold and flu are mostly due to viral infection.
Take annual (once a year) influenza vaccine.

Hope I have solved your query.
You can ask me directly at bit.ly/askdrkaushalbhavsar.

Wish you good health.
Thanks.

Note: For further information on diet changes to reduce allergy symptoms or to boost your immunity, Ask here.

Above answer was peer-reviewed by : Dr. Arnab Banerjee