
What Causes Persistent High Blood Pressure Despite Taking Metoprolol?

I would recommend as follows:
Detailed Answer:
Hello!
Welcome and thank you for asking on HCM!
Regarding your concern, I would explain that Metoprolol is not the best treatment against high blood pressure. Its main action is to reduce the heart rate, but it has also a weak anti-hypertensive effect.
Anyway, before starting treatment it is necessary performing some tests to investigate for the possible causes underlying uncontrolled high blood pressure:
-a chest X ray study
- a resting ECG and cardiac ultrasound
- complete blood count for anemia
- thyroid hormone levels for thyroid dysfunction
- cortisol and aldosterone plasma levels for adrenal gland dysfunction
- kidney and liver function tests
- PCR and ESR for inflammation
- blood electrolytes for possible imbalance
- fasting glucose and HbA1C levels for diabetes.
Regarding the treatment, you should know that when dealing with a malignant high blood pressure, a combined therapy of different anti-hypertensive drugs is necessary. A possible combination would be a diuretic (hydrochlorothyazide), an ARB (irbesartan, olmesartan, etc.) combined with Metoprolol.
Other treatment options would be calcium channel blockers (amlodipine, etc.).
You should discuss with your doctor on the above issues.
Hope you will find this answer helpful!
Kind regards,
Dr. Iliri

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