Question: Hello. I am a 46 yr old female who has been experiencing a lot of unpleasant neurological symptoms for 2 years. It started with adrenaline feelings and swells that would wake me at night with racing heart. Then I started to get head rush/pressure feelings in my head with facial pain, facial tightness, twitching and nausea and arrytmias. This went on for a while, disturbing sleep. They were like "attacks." Then my entire body began twitching randomly throughout. I also have shooting burning muscle and nerve pains in my limbs, especially at night, with cold sensations. I also feel like my brain is "burning" and "tingly" and I have a lot of constant pain in the back of my head and neck. Like the occiptial is clenching. Also, feel tongue spasms, like my mouth and cheeks are swollen but they are not, and I feel like I am "teething." I also feel agitated and anxious, but it does not feel like its from psychological anxiety.

My question is really about my brain MRI: It shows a "solitary white matter plaque at the subcortical plain (4.1 millimeters). There is no cortical lesion or dysplasia or other evidence for white matter plaque. The gradient echo demonstrates 4 foci of susceptibility which could reflect microhemorrhage. These are present in the right lateral cerebellum, left parietotemporal region, right posterior frontal region and left middle frontal region. There may be an additional plaque at the left dentate nucleus on gradient. The pattern is not typical for shear injury and these are not in the typical distribution for amyloid. There is no evidence for abnormal iron distribution along the venous pathway." A second MRI on a lesser quality machine said they could be cavernous malformations. This MRI that I quoted was done on a 3Tesla.

What does this mean? None of the drs can provide an explanation for them. I have had the 4.1 millimeter plaque for 17 yrs but this is the first time (I haven't been scanned in 17 yrs) that we see microbleeds. None of the drs said that these could cause my symptoms. What does not in the distribution for amlyoid mean? Why are these not in that distribution? Also, could these be cancer? (I have no history).

I do not have a vomiting history. A little bit of a headache issue. Now its more burning or pressure.

I do have anticardiolipin antibodies for the past 10 years in my blood and a low positive ANA. I also recently had reactivated Epstein barr virus and cytomegalovirus. It looks like I had LYme in the past as well.

I did have a mitral valve repair for mv prolapse 7 years ago.

All of the other tests are normal, except I have had a polyclonal IgM in my blood for the past 15 yrs as well (no monoclonal protein) that no one can identify.

Is it possible I have some immune neuropathy?