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What Could Cause Watery Diarrhea For Over Two Months When No Medication Has Helped So Far?

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Posted on Mon, 9 Oct 2023
Question: I HAVE HAD PURE WATER DIARRHEA FOR OVER TWO MONTHS. NOTHING HELPS. MY DOCTOR PUT ME ON A Z-PAK, ANOTHER ANTIBIOTIC I HAD NEVER HEARD OF, NOW 3 DAYS OF CIPRO. NOTHING IS WORKING. I AM TAKING LOMOTIL AND IT DOES NOT HELP. MY DOCTOR DID A STOOL CULTURE FOR ECOLI AND SOMETHING ELSE - BUT CAME BACK NEGATIVE.

I AM WEAK AND LOSING WEIGHT. HE SAYS HE DOESN'T KNOW WHAT TO DO. I CANNOT GET INTO A GI SPECIALIST UNTIL LATE MAY.
WHAT CAN I DO TO STOP THIS? THANK YOU!
doctor
Answered by Dr. Ramesh Kumar (28 minutes later)
Brief Answer:
It can be due to IBS.

Detailed Answer:

Hi,

I've gone through your details.
I am Dr Kumar and would be addressing your concerns.
As per your queries answer is see it could not be simple enteritis as you have been given all sorts of medications used to treat it and you are not responding.
Possibility is that it could be irritable bowel disease.
However IBS is a diagnosis of exclusion as there is no test to confirm you have IBS,It means that when you have nothing or all your investigations are normal you are labelled as having IBS.
what exactly is IBS?
A common disorder affecting the large intestine is the Irritable Bowel Syndrome. Abdominal pain, resistant diarrhoea are some of the signs and symptoms of IBS. Foods, stress and other diseases can trigger the problem.
However the exact cause of irritable bowel syndrome is not yet known but studies suggest that a lot of factors play a major role.
The structure of the intestines is normal, only functional abnormality occurs in this condition.So frankly speaking (IBS) represents a functional disorder of gastrointestinal tract without the presence of an anatomic defect.
So in lay mans language till date we are not sure whats the exact cause of this problem.So the million dollar question is how to repair a system when you don't know which part of it is faulty(Some says it can be brain other says it can be hormone anxiety age etc etc).

Some patients have symptoms of unformed stools some have bloating and some may have severe constipation. Some patients have occasional symptoms whereas others may have symptoms for a long period of time.So as seen above every patient is different.Intensity of symptoms in every patient is different as so is the response to medicines and life style change.A patient may respond good to one medication while other patient is totally unresponsive to the same.

Our goal in your case-
Every drug is not effective in every patient so we have to try different therapies till we find the drug which suits best our patient.All the below mentioned drugs slows down motility of intestines hence will decrease both frequency of motions as well as will increase your power to control them.


Dicyclomine is an anticholinergic drug.An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.

Mebeverine is an antispasmodic medicine and is very useful in IBS and is well tolerated by patient with minimal side effects. Mebeverine works on certain muscles in the wall of your intestines, causing them to relax.
Clidinium bromide is an anticholinergic (specifically a
It may help symptoms of frequent stools.

Chlordiazepoxide works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.Can be used in combination with above mentioned medicines.


Ask your Gastroenterologist to start you initially on clidinium bromide and mebeverine combination initially for 21 days.

Get a colonoscopy test done.
After taking these medicine things should improve.
Thsnks!
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Above answer was peer-reviewed by : Dr. Raju A.T
doctor
Answered by
Dr.
Dr. Ramesh Kumar

Gastroenterologist

Practicing since :1986

Answered : 2913 Questions

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What Could Cause Watery Diarrhea For Over Two Months When No Medication Has Helped So Far?

Brief Answer: It can be due to IBS. Detailed Answer: Hi, I've gone through your details. I am Dr Kumar and would be addressing your concerns. As per your queries answer is see it could not be simple enteritis as you have been given all sorts of medications used to treat it and you are not responding. Possibility is that it could be irritable bowel disease. However IBS is a diagnosis of exclusion as there is no test to confirm you have IBS,It means that when you have nothing or all your investigations are normal you are labelled as having IBS. what exactly is IBS? A common disorder affecting the large intestine is the Irritable Bowel Syndrome. Abdominal pain, resistant diarrhoea are some of the signs and symptoms of IBS. Foods, stress and other diseases can trigger the problem. However the exact cause of irritable bowel syndrome is not yet known but studies suggest that a lot of factors play a major role. The structure of the intestines is normal, only functional abnormality occurs in this condition.So frankly speaking (IBS) represents a functional disorder of gastrointestinal tract without the presence of an anatomic defect. So in lay mans language till date we are not sure whats the exact cause of this problem.So the million dollar question is how to repair a system when you don't know which part of it is faulty(Some says it can be brain other says it can be hormone anxiety age etc etc). Some patients have symptoms of unformed stools some have bloating and some may have severe constipation. Some patients have occasional symptoms whereas others may have symptoms for a long period of time.So as seen above every patient is different.Intensity of symptoms in every patient is different as so is the response to medicines and life style change.A patient may respond good to one medication while other patient is totally unresponsive to the same. Our goal in your case- Every drug is not effective in every patient so we have to try different therapies till we find the drug which suits best our patient.All the below mentioned drugs slows down motility of intestines hence will decrease both frequency of motions as well as will increase your power to control them. Dicyclomine is an anticholinergic drug.An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. Mebeverine is an antispasmodic medicine and is very useful in IBS and is well tolerated by patient with minimal side effects. Mebeverine works on certain muscles in the wall of your intestines, causing them to relax. Clidinium bromide is an anticholinergic (specifically a It may help symptoms of frequent stools. Chlordiazepoxide works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.Can be used in combination with above mentioned medicines. Ask your Gastroenterologist to start you initially on clidinium bromide and mebeverine combination initially for 21 days. Get a colonoscopy test done. After taking these medicine things should improve. Thsnks!