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What Do These Following Lab Reports Indicate?
Question: Hi
My wife is now 10 weeks pregnant as on today - 03/05/2016. We did first blood work in 8th Week, and her Rubella Igm test came out positive with high values and IGG came just above XXXXXXX limit and IGG avidity also slightly above high limit.
We got multiple tests done from 2 different labs, and all relevant reports are attached.
We are not sure, should we terminate the pregnancy or there is chance we can continue. Currently our doctor has advised to wait 2 more weeks and do rubella Igm & Igg tests again to see rise in Igg values.
But we are so much confused, and in doubtful situation.If igg values XXXXXXX in 2 weeks, i think we should terminate due to primary infection but what if Igg does not rise and remain same, can we be sure, there will be no risk of rubella while Igm is so high.
And if this is not primary infection, then why Igg is not very high but just on border.
Also then IGG avidity is high which usually comes in few months.
(As per wife parents they don't recall if she got rubella vaccination but probably not).
All Reports
1) 1st test (igg & Igm) from Dr. Dang Lab on 17th April'16
IGG ® REACTIVE 11.0 ( 0 - 10)
IU/mL
IGM ® REACTIVE 3.03 ( 0 - 1.2)
2) Re-test (igg & igm ) from Dr Dang Lab and Igg avidity from Dr Lal lab - 23 rd April'16
(Dr Dang does not have avidity test)
IGG - 10.6 IU/ml (0-10 range)
IGM - 3.010 (0 - 1.2 range)
IGG Avidity - 49.2 % (< 30 low, 30-40 Equivocal, > 40 high)
3) Re-test (igg, igm, igg avidity) from XXXXXXX XXXXXXX hospital on 26th April16. - This was done as per our doctor recommendation since this hospital has best lab kit.
IGM - 3.13
IGG - 17 ( 15 positive).
IGG Avidity - 63% ( 60 high)
My wife is now 10 weeks pregnant as on today - 03/05/2016. We did first blood work in 8th Week, and her Rubella Igm test came out positive with high values and IGG came just above XXXXXXX limit and IGG avidity also slightly above high limit.
We got multiple tests done from 2 different labs, and all relevant reports are attached.
We are not sure, should we terminate the pregnancy or there is chance we can continue. Currently our doctor has advised to wait 2 more weeks and do rubella Igm & Igg tests again to see rise in Igg values.
But we are so much confused, and in doubtful situation.If igg values XXXXXXX in 2 weeks, i think we should terminate due to primary infection but what if Igg does not rise and remain same, can we be sure, there will be no risk of rubella while Igm is so high.
And if this is not primary infection, then why Igg is not very high but just on border.
Also then IGG avidity is high which usually comes in few months.
(As per wife parents they don't recall if she got rubella vaccination but probably not).
All Reports
1) 1st test (igg & Igm) from Dr. Dang Lab on 17th April'16
IGG ® REACTIVE 11.0 ( 0 - 10)
IU/mL
IGM ® REACTIVE 3.03 ( 0 - 1.2)
2) Re-test (igg & igm ) from Dr Dang Lab and Igg avidity from Dr Lal lab - 23 rd April'16
(Dr Dang does not have avidity test)
IGG - 10.6 IU/ml (0-10 range)
IGM - 3.010 (0 - 1.2 range)
IGG Avidity - 49.2 % (< 30 low, 30-40 Equivocal, > 40 high)
3) Re-test (igg, igm, igg avidity) from XXXXXXX XXXXXXX hospital on 26th April16. - This was done as per our doctor recommendation since this hospital has best lab kit.
IGM - 3.13
IGG - 17 ( 15 positive).
IGG Avidity - 63% ( 60 high)
Brief Answer:
Rubella in first timester can have devastating consequences.
Detailed Answer:
Thanks for asking on HealthcareMagic.
I have gone through your query very carefully. I am more interested in the IgM report since it indicates recent infection. IgM is positive in her case and therefore indicates a recent infection of rubella. Rubella can be a serious threat to your pregnancy, especially during the first and second trimesters. Having rubella during pregnancy increases the risk of:
Congenital rubella syndrome (CRS) – This is a condition that happens when a mother passes rubella to her baby during pregnancy. It may cause a baby to be born with one or more birth defects, including heart problems, microcephaly, vision problems, hearing problems, intellectual disability, bone problems, growth problems, and liver and spleen damage.
Miscarriage – This is when a baby dies in the womb before 20 weeks of pregnancy.
Stillbirth – This is when a baby dies in the womb after 20 weeks of pregnancy.
Premature birth – This is birth that happens too early, before 37 weeks of pregnancy.
At this juncture you have two options:
* Decide to continue the pregnancy with the above mentioned risks, you can go ahead with the pregnancy.
* If you are not ready to bear the risks, proceed towards termination of the pregnancy.
You would have to make the hard choice.
Regards
Rubella in first timester can have devastating consequences.
Detailed Answer:
Thanks for asking on HealthcareMagic.
I have gone through your query very carefully. I am more interested in the IgM report since it indicates recent infection. IgM is positive in her case and therefore indicates a recent infection of rubella. Rubella can be a serious threat to your pregnancy, especially during the first and second trimesters. Having rubella during pregnancy increases the risk of:
Congenital rubella syndrome (CRS) – This is a condition that happens when a mother passes rubella to her baby during pregnancy. It may cause a baby to be born with one or more birth defects, including heart problems, microcephaly, vision problems, hearing problems, intellectual disability, bone problems, growth problems, and liver and spleen damage.
Miscarriage – This is when a baby dies in the womb before 20 weeks of pregnancy.
Stillbirth – This is when a baby dies in the womb after 20 weeks of pregnancy.
Premature birth – This is birth that happens too early, before 37 weeks of pregnancy.
At this juncture you have two options:
* Decide to continue the pregnancy with the above mentioned risks, you can go ahead with the pregnancy.
* If you are not ready to bear the risks, proceed towards termination of the pregnancy.
You would have to make the hard choice.
Regards
Note: For detailed guidance on genetic screening consult a genetics specialist
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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