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What Does A Decrease In CEA By Ten Points After Chemotherapy Indicate?

Posted on Thu, 18 Jun 2015

Question: Cana decrease in cea of 10 points after 2 rounds of chemotherapy mean anything at all for metastic colon cancer ?

Answered by Dr. Indu Kumar (1 hour later)

Brief Answer:
It may indicate good treatment response.

Detailed Answer:
Hello

Decrease in CEA by ten points after 2 rounds of chemotherapy can be considered as a good sign.
It may indicate good treatment response.

Patient should continue full course of chemotherapy and go for regular CEA estimation.

Get well soon.
Hope I have answered your question.
Further queries are most welcome

Take Care
Dr.Indu XXXXXXX

Above answer was peer-reviewed by : Dr. Shanthi.E

Follow up: Dr. Indu Kumar (4 hours later)

Please advise I'm
Confussed. Ct scan done recent this week, one done on March and on in January .

In march Apparantly there were several liver mets but this recent one only give measurements of 2. Do rafiologist tend to only mention larger ones ?

Answered by Dr. Indu Kumar (8 minutes later)

Brief Answer:
Yes,only larger lesions are mentioned conventionally.

Detailed Answer:
Hello

Yes,if there are many lesions then generally only measurement of larger lesions are mentioned in the report.
Measurement of every metastatic lesions is not required for proper management.Treatment will be same irrespective of number and size of metastatic lesions.

Get well soon.
Hope I have answered your question.
Further queries are most welcome

Take Care
Dr.Indu XXXXXXX

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Indu Kumar (3 hours later)

Cea drop but still showed cancer progression in scan ... What cN be done ?

Answered by Dr. Indu Kumar (16 hours later)

Brief Answer:
Only option is to continue chemotherapy.

Detailed Answer:
Hello,
Sorry for replying late.

Only option is to continue chemotherapy and it is the best appropriate treatment.
We should accept that it is fourth stage and not much options are left.
Surgical resection of larger liver lesions can be done if needed.
Since CEA is decreasing,we should expect good results.

Get well soon.
Hope I have answered your question.
Further queries are most welcome

Take Care
Dr.Indu XXXXXXX

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Indu Kumar (11 minutes later)

But cea decreased at round 2 to 55 but still
Liver lesions grew and peritoneal
Lesions , so does this mean chemo not worked ? Only 1 node ghey say has reduced

Answered by Dr. Indu Kumar (3 hours later)

Brief Answer:
I suggest for repeat CEA estimation as reports are conflicting.

Detailed Answer:
Hello,

Good treatment response is indicated by decrease of both CEA and tumour size.
We expect simultaneous decrease in both factors.Increase in size of tumour but decrease in CEA value is conflicting.I suggest for repeat CEA estimation.
Presently you should continue chemotherapy.It is the best appropriate treatment.

Get well soon.
Hope I have answered your question.
Further queries are most welcome

Take Care
Dr.Indu XXXXXXX

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Indu Kumar (16 minutes later)

Yes the cea have been repeated to double check
And the above r the exact readings . So I don't know of mets have increased y cea decreased ?

Answered by Dr. Indu Kumar (19 minutes later)

Brief Answer:
Increase in tumour size may indicate disease progression.

Detailed Answer:
Hello,

As it is confirmed that CEA level is decreased but there is increase in tumour size,it may indicate disease progression.Increase in tumour size is considered as more important prognostic factor.

Get well soon.
Hope I have answered your question.
Further queries are most welcome

Take Care
Dr.Indu XXXXXXX

Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar