
What Does Cervical Changes And Positive HPV Indicate?

Question: Approximately 2 years ago I was diagnosed with ASCUS cervical changes and positive for HPV (however negative for strains 16 and 18). Colposcopy and biopsy indicated minimal cell changes and I have been monitored with repeat Pap smears every 6 months ever since. My last 2 Pap smears after the biopsy have been normal. My most recent Pap smear came back with indication of high grade cervical dysplasia and I am now scheduled for another colposcopy and biopsy in one month. If high grade dysplasia is confirmed recommendation is likely going to be conization. I have been sexually active for 5 years with 2 previous partners. I have had no new partners or other changes in sexual history since initial diagnosis so it is highly unlikely that I have been exposed to a new HPV strain. I am a non-smoker and am not immuno-compromised. My concern is that this finding seems quite atypical. Should I be concerned that dysplasia seems to have progressed so quickly? Maybe this is more common than I think, however I am now starting to question the previous or current examinations. Would it be in my best interest to seek a second opinion to ensure the consistency of these findings?
Brief Answer:
Second opinion is required.
Detailed Answer:
Hello,
Thanks for trusting us with your health concern.
A high grade cervical dysplasia diagnosed now with a normal PAP sear 6 months ago is an unexpected rapid progression of the dysplasia.
ASCUS PAP sear results are a common finding and it usually does not progress to dysplasia in 2 years.
It is best to get a second opinion and get a repeat PAP smear performed to confirm the findings.
Please feel free to discuss further. I will be glad to answer the follow up queries that you have.
Wishing you good health.
Regards.
Dr. Rakhi Tayal.
For future query, you can directly approach me through my profile URL http://bit.ly/Dr-Rakhi-Tayal
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar

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