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What Does Raised APTT Indicate?

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Posted on Mon, 7 Apr 2014
Question: My wife is 46. Always had excellent results on blood tests from yearly physicals. About a year ago she had a retina detachment. First surgery was to put a bubble. Second surgery to insert oil. Third surgery to remove oil. Then forth to remove cataract which was a byproduct of the procedures. She has been on long lasting atropine for about a year. For the post cataract procedure she is on nevanac,prednisolon, durezol. Her latest blood work showed a high aptt result of 40.8. Our Dr recommended seeing a hematologist but it will take 2 months. Recently after she eats she feels her throat swelling. Any ideas? Are these related? Are these drug effects?
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Answered by Dr. Rakesh Karanwal (10 hours later)
Brief Answer: Problem probably due to oral allergy to food/drug Detailed Answer: Hi friend, Thanks for your query. 1. RAISED aPTT :- A raised aPTT is an indicator of a delayed clot formation. The normal range of the test is 20-40 seconds. Hence, a value of 40.8 seconds, is negligibly higher than the upper limit of normal range. Please intimate if your wife has ever had prolonged bleeding following a cut/wound. If not, I would recommend that the test should be repeated at a different Laboratory. 2. THROAT SWELLING :- The commonest cause of a transient throat swelling following ingestion of food, is a mild food intolerance/allergy. You have not mentioned if there are other symptoms associated with throat swelling; or, recurrent symptoms of common cold, hives, itching etc. Nevertheless, she has probably developed Oral Allergy Syndrome, a condition in which symptoms are immediate upon ingestion of fresh or uncooked foods and include the itching, irritation, and mild swelling of the lips, tongue, palate, and throat.The symptoms usually go away within minutes. Usually, cooked foods do not cause such reactions. Of the drugs, Nevanac eye drops, can cause local allergy in the throat when it flows down from the eye through lacrimal tube and come into contact with the throat. Allergy to other drugs is unlikely. Additional information- such as, dietary contents, linkage of symptoms to a particular food like fruits, nuts, fish, eggs, shellfish etc.- in greater detail would be extremely helpful for me to pinpoint the likeliest cause of transient throat swelling. Hope I have addressed your concerns to your complete satisfaction and you find my response helpful and informative. I will be happy to answer further queries, if any. In any case, I would be keenly awaiting additional input from you. Take care Dr. Rakesh Karanwal
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Above answer was peer-reviewed by : Dr. Prasad
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Dr. Rakesh Karanwal

Internal Medicine Specialist

Practicing since :1980

Answered : 1357 Questions

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What Does Raised APTT Indicate?

Brief Answer: Problem probably due to oral allergy to food/drug Detailed Answer: Hi friend, Thanks for your query. 1. RAISED aPTT :- A raised aPTT is an indicator of a delayed clot formation. The normal range of the test is 20-40 seconds. Hence, a value of 40.8 seconds, is negligibly higher than the upper limit of normal range. Please intimate if your wife has ever had prolonged bleeding following a cut/wound. If not, I would recommend that the test should be repeated at a different Laboratory. 2. THROAT SWELLING :- The commonest cause of a transient throat swelling following ingestion of food, is a mild food intolerance/allergy. You have not mentioned if there are other symptoms associated with throat swelling; or, recurrent symptoms of common cold, hives, itching etc. Nevertheless, she has probably developed Oral Allergy Syndrome, a condition in which symptoms are immediate upon ingestion of fresh or uncooked foods and include the itching, irritation, and mild swelling of the lips, tongue, palate, and throat.The symptoms usually go away within minutes. Usually, cooked foods do not cause such reactions. Of the drugs, Nevanac eye drops, can cause local allergy in the throat when it flows down from the eye through lacrimal tube and come into contact with the throat. Allergy to other drugs is unlikely. Additional information- such as, dietary contents, linkage of symptoms to a particular food like fruits, nuts, fish, eggs, shellfish etc.- in greater detail would be extremely helpful for me to pinpoint the likeliest cause of transient throat swelling. Hope I have addressed your concerns to your complete satisfaction and you find my response helpful and informative. I will be happy to answer further queries, if any. In any case, I would be keenly awaiting additional input from you. Take care Dr. Rakesh Karanwal