Brief Answer:
all antidepressants can cause weight gain.

Detailed Answer:
Hello
Welcome to HCM.
I can understand your concerns.
I have seen your reports thoroughly.

First regarding the reports, I do not think these reports to be clinically useful.
The reason being that your report shows you have increased risk of side effects (especially weight gain) with atypical antipsychotics.
This is a possibility with every individual irrespective of DNA reports (which is not feasible in every patient).

The report shows that you can do well with most of the drugs (those ticked in green column. These drugs are anyhow the treatment options for anyone.

So, in my opinion, this report does not carry much clinical significance.

Now coming to your treatment part:
All antidepressants can cause weight gain (SSRIs, SNRIs, TCAs etc.) except wellbutrin which is considered to be weight neutral.

Before adding any other drug, I would suggest a dose increment of zoloft.
The maximum dose of zoloft for depression is 200mg.

If there is still no effect with maximum dose, then you can think of SNRI like desvenalfaxine (do not worry about weight gain specifically with SNRIs because every antidepressant can cause weight gain).

To prevent weight gain, you would have to go for daily physical exercises and avoid fatty and junk food.

Kindly discuss this with your psychiatrist.

Hope I am able to clear your confusion to some extent.

Feel free to ask further.

I wish you well.
Thanks.

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Brief Answer:
effexor not a good choice.

Detailed Answer:
Hi again.

As per your reports, the atypical antipsychotic drugs can cause adverse effects (especially weight gain) in you.
(This is anyhow the fact that antipsychotic drugs cause weight gain in all).

Regrading combination, drugs those ticked in green column are safe for you.

You have been given high dose of zoloft in past which led to weight gain, without much improvement in symptoms.
(You did not mention this in your query earlier).

Increasing the dose of zoloft again is not a good idea then.

Effexor with wellbutrin can cause potential drug interactions. I would not recommend this combination.
Pristiq (desvenlafaxine) in low doses is relatively safe and better tolerated then effexor.

Stimulants can also be considered in your cases.
But I would prefer armodafinil (very less abuse potential) over dexedrine (more abuse potential).

Kindly discuss this with your doctor.

Feel free to ask further.
I wish you well.
Thanks.

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Brief Answer:
wellbutrin alone would not be sufficient.

Detailed Answer:
You are most welcome.

Your report recommends use of dexedrine.
But this does not indicates that you are low in dopamine.
Neither does it suggests that you have ADHD.
ADHD is a clinical diagnosis primarily and is diagnosed on basis of criteria laid in DSM/ICD.

I do not think wellbutrin alone would be sufficient for you. It is a weaker antidepressant as compared to others.

Your report has listed almost all the antidepressants and their possibility of use in your case.
Stimulants and omega-3 fatty acids are among those. But then, these are not the first line or even second line antidepressants.

I doubt that natural ways to elevate serotonin would be enough.
Exercises or simple brisk walking for 30 minutes, some foods like legumes and potatoes can help to increase serotonin.
Avoid caffeine. Ensure adequate exposure to light.
These strategies are just supplementary and does not replace drugs.

So, in my opinion,
Wellbutrin alone would not be sufficient.
Add pristiq or a stimulant (preferably armodafinil).
Exercise regularly.

Discuss these issues with your doctor.

You can confirm about number of follow-up questions from the site moderators.

Hope my suggestions have helped you.

Kindly close the discussion if you have no more queries and give your valuable feedback.

Take care.
Thanks.

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