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What Is Concern With The Medicine And Use For Anyone With Obstructive Sleep Apnea?

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Posted on Fri, 19 Jul 2024
Question: Hi,

I started having a sort of dry sensation in my throat about 6 days ago which then developed into a cough with phlegm. I also had a sore and stiff neck at the time.

My symptoms seem to be related to nasal drip. Is it possible that the cause could be viral given I had no temperature? My COVID antigen test was also negative. I believe my symptoms started before trialing a CPAP for sleep apnea but could the machine contribute to the symptoms?

I have taken lozenges but pholcodine is no longer available in cough medicine as it is considered unsafe. Are lozenges with dextromethorphan or dihydrocodeine phosphate still considered safe? I note that codeine is now no longer available OTC where I live. The instructions say that a contraindication for the use of dihydrocodeine is obstructive sleep apnea. What is concern with the medicine and use for anyone with obstructive sleep apnea?



Thank you,
Regards.
doctor
Answered by Dr. Dr. Naveen Kumar Nanjasetty (28 hours later)
Brief Answer:
Avoid using any medications with codeine...

Detailed Answer:
Hi

Thanks for posting the query.

The symptoms you have described could have been secondary to the upper respiratory tract infection probably of viral origin. CPAP machine usage can contribute to dryness in the throat.

Even though the CPAP machine can humidify the air which it releases into the nose and throat; the excess inflow of air can lead to dryness.

Codeine is usually given for dry cough which is not relieved by routine medications. Basically, as a cough suppressant. If you have a productive cough, then you would require either Ambroxol or Bromhexine.

Codeine is not given in obstructive sleep apnoea because it can depress the respiratory center furthermore.

The post-nasal drip can be secondary to the GERD as well; the proton pump inhibitors would be beneficial in this condition.

Drink frequent sips of lukewarm water. Avoid coffee.

I hope this answers your query. Revert if you have any follow-up queries.

Thanks and regards
Dr. Naveen Kumar N
ENT and Head & Neck Surgeon
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Dr. Naveen Kumar Nanjasetty (39 hours later)
Dear,

Thank you for the reply and information.

I am still having phlegm from the cough. Initially it was a little yellow and then turned white but now it is back to a yellow colour. Does this indicate ongoing or returning infection in the respiratory tract? Or it is expected that sometimes the phlegm will be yellow with postnasal drip?

Is there any difference between codeine and dihydrocodeine in terms of acceptable usage? In any case, I won't use it for my phlegm cough as it meant for dry cough.

For my cough, how can it be determined if it needs to be treated with antibiotics?


Thank you,
Regards,
doctor
Answered by Dr. Dr. Naveen Kumar Nanjasetty (41 hours later)
Brief Answer:
Whitish or yellowish phlegm denotes mild or resolving infection

Detailed Answer:
Hi

Welcome back

My sincere apologies for the delay in the response.

Does this indicate ongoing or returning infection in the respiratory tract?
A: Whitish or yellowish phlegm denotes mild or resolving infection. The black-colored sputum could be a mixture of the old blood clots in the sputum.

Or is it expected that sometimes the phlegm will be yellow with a postnasal drip?
A: Yellowish phlegm can also be seen in allergic nose conditions, which is normal.

Is there any difference between codeine and dihydrocodeine in terms of acceptable usage?
A: The efficacy of dihydrocodeine is twice as compared to that of codeine. Both are used in various conditions depending upon the symptoms and their severity.

For my cough, how can it be determined if it needs to be treated with antibiotics?
A: If the cough is noticed for more than 4-5 days and not relieving with simple measures, then the antibiotics are started after doing a blood test. The first 4-5 days of the upper respiratory tract would be viral in origin and hence doesn't require any antibiotics. Later on, it may become bacterial, requiring basic investigations and antibiotics accordingly. In your case, antibiotics would give you relief from the cough and expectoration.

I hope this clarifies your doubts. I wish you good health and a speedy recovery.

Regards
Dr. Naveen Kumar N
ENT and Head & Neck Surgeon
Above answer was peer-reviewed by : Dr. Saisudha Kotla
doctor
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Follow up: Dr. Dr. Naveen Kumar Nanjasetty (23 hours later)
Dear Dr. XXXXXXX

Thank you for the reply and information.

Just to clarify I don't have any black phlegm.

In short, would it be expected that dihydrocodeine has the same associated risks as codeine or is it really a different type of medication?

What type of blood tests would be recommended to see if the cough is now bacterial in cause?



Thank you,
Regards.
doctor
Answered by Dr. Dr. Naveen Kumar Nanjasetty (1 hour later)
Brief Answer:
A complete blood count would help in identifying the bacterial infection

Detailed Answer:
Hi

Thanks for writing back

1. Even though Dihydrocodeine and Codeine belong to the same family the former has relatively fewer side effects compared to the latter. On the efficacy front, Dihydrocodeine is better than codeine.

2. A complete blood count would help in identifying the bacterial infection. The increase in White Blood Cells (WBC) indicates a bacterial infection.

I hope I have answered your queries. Wish you good health.

Regards
Dr. Naveen Kumar N
ENT and Head & Neck Surgeon
Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
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Follow up: Dr. Dr. Naveen Kumar Nanjasetty (2 days later)
Thanks Dr. XXXXXXX

Just to follow up the cause as being possibly secondary to GERD, how would this work?

Would the irritation of the reflux cause more mucus in the throat? How would it affect the level of mucus or phlegm from the nasal area or would the phlegm produced just become more irritating to the nasal and throat linings?



Thank you,
Regards
doctor
Answered by Dr. Dr. Naveen Kumar Nanjasetty (9 hours later)
Brief Answer:
Laryngopharyngeal reflux is a silent regurgitation of the acid from stomach

Detailed Answer:
Hi

Welcome back

Laryngopharyngeal reflux is a silent regurgitation of acid from the stomach into the throat leading to mucosal inflammation of the latter. The reflux of the acid can reach up to the back of the nose in the lying down position. The body secretes excess saliva or thick discharge (phlegm) to alleviate the mucosal inflammation, which is perceived in the throat as post-nasal drip.

The symptoms worsen when there is an attack of upper respiratory tract infection or nasal allergy.

The best way to eliminate this issue is to make lifestyle modifications and take a few medications to prevent Laryngopharyngeal reflux.

My suggestions to you are:
1. Drink frequent sips of warm water
2. Take medications for acid reflux, such as Proton pump inhibitors.
3. Avoid coffee, chilled food, and beverages
4. Avoid stress, do exercises regularly

I hope your doubts are cleared. I wish you good health.

Regards
Dr. Naveen Kumar N.
ENT and Head & Neck Surgeon
Above answer was peer-reviewed by : Dr. LAKSHMI
doctor
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Follow up: Dr. Dr. Naveen Kumar Nanjasetty (2 days later)
Thank you Dr. XXXXXXX

Appreciate the detailed explanation. Lastly I just wanted to check if the explanation of reflux would be consistent with less phlegm being produced while lying flat or sleeping as the issue seems to arise mainly during the day and not when lying down when not much phlegm is produced.



Thank you and Regards.
doctor
Answered by Dr. Dr. Naveen Kumar Nanjasetty (22 hours later)
Brief Answer:
During sleep, the swallowing effort would be less...

Detailed Answer:
Hi

Thanks for writing back

During sleep, the swallowing effort would be less compared to that when we are awake. Normally, when there is inflammation in the mucosa of the nasopharynx (back of the nose) and oropharynx (throat) we make a constant effort to relieve the discomfort. This causes friction of the soft palate and the back of the tongue over the pharyngeal wall irritating the mucosa further. The constant friction stimulates the mucosa to enhance the secretions thereby increase in the post-nasal discharge.

The irritation gets relieved when we drink warm water and thus a reduction in the quantity of the secretions. Similarly, the proton pump inhibitors reduce gastric secretions alleviating acid reflux and throat irritation.

Hope this explanation clarifies your doubts. God bless you with good health.

Regards
Dr. Naveen Kumar N
ENT and Head & Neck Surgeon
Note: Consult an experienced Otolaryngologist / ENT Specialist online for further follow up on ear, nose, and throat issues - Book a Call now.

Above answer was peer-reviewed by : Dr. Raju A.T
doctor
Answered by
Dr.
Dr. Dr. Naveen Kumar Nanjasetty

Otolaryngologist / ENT Specialist

Practicing since :2001

Answered : 2542 Questions

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What Is Concern With The Medicine And Use For Anyone With Obstructive Sleep Apnea?

Brief Answer: Avoid using any medications with codeine... Detailed Answer: Hi Thanks for posting the query. The symptoms you have described could have been secondary to the upper respiratory tract infection probably of viral origin. CPAP machine usage can contribute to dryness in the throat. Even though the CPAP machine can humidify the air which it releases into the nose and throat; the excess inflow of air can lead to dryness. Codeine is usually given for dry cough which is not relieved by routine medications. Basically, as a cough suppressant. If you have a productive cough, then you would require either Ambroxol or Bromhexine. Codeine is not given in obstructive sleep apnoea because it can depress the respiratory center furthermore. The post-nasal drip can be secondary to the GERD as well; the proton pump inhibitors would be beneficial in this condition. Drink frequent sips of lukewarm water. Avoid coffee. I hope this answers your query. Revert if you have any follow-up queries. Thanks and regards Dr. Naveen Kumar N ENT and Head & Neck Surgeon